c-Myc accelerates S-phase and requires WRN to avoid replication stress.

c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown. Here, we show that c-Myc overexpression in primary human fibroblasts...

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Bibliographic Details
Published in:PLoS ONE
Main Authors: Kristin Robinson, Nichaya Asawachaicharn, Denise A Galloway, Carla Grandori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Online Access:http://europepmc.org/articles/PMC2694031?pdf=render

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