| 總結: | Canine Visceral Leishmaniasis (CVL) and Canine Monocytic Ehrlichiosis (CME) are
zoonotic diseases that cause coagulation disorders, abnormalities in various organs and
systems along with vasculitis. Since it was reported that the presence of co-infection may
cause more severe abnormalities, this study aimed to investigate the synergistic effects
of co-infection on some coagulation analytes (prothrombin time (PT), activated partial
thromboplastin time (APTT), fibrinogen (FIB) and D-Dimer). Twenty dogs, all were
mixed breed, aged 2-4 years, and determined to be co-infected with CVL and CME were
used. As a result of the coagulation profile analyte measurements, the values of APTT,
PT, and the concentration of FIB were determined to be higher in the Co-infected Group
compared to the Control Group (p<0.05). Receiver operating characteristic (ROC)
analysis revealed that PT (AUC: 0.980); APTT (AUC: 0.959), FIB (AUC: 1.000), and
D-dimer (AUC: 0.929) had outstanding diagnostic discrimination. As a result, it was
concluded that the presence of co-infection deteriorates the coagulation profile more
severely in co-infection with CVL and CME.
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