Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone loss

Abstract Background Chrysosplenetin is an O-methylated flavonol compound isolated from the plant Chamomilla recutita and Laggera pterodonta. The aim of our research is to evaluate the function of Chrysosplenetin on osteogenesis of human-derived bone marrow stromal cells (hBMSCs) and inhibition of es...

Full description

Bibliographic Details
Published in:	Stem Cell Research & Therapy
Main Authors:	Guoju Hong, Xiaoming He, Yingshan Shen, Xiaojun Chen, Fang Yang, Peng Yang, Fengxiang Pang, Xiaorui Han, Wei He, Qiushi Wei
Format:	Article
Language:	English
Published:	BMC 2019-08-01
Subjects:	Chrysosplenetin BMSC Osteoblast Wnt/β-catenin DKK1 Noggin
Online Access:	http://link.springer.com/article/10.1186/s13287-019-1375-x

Similar Items

Chrysosplenetin B suppresses the growth of human prostate cancer cells by inducing G1 cell cycle arrest
by: Gang He, et al.
Published: (2025-03-01)

Biological potential and therapeutic benefit of Chrysosplenetin: An Applications of polymethoxylated flavonoid in medicine from natural sources
by: Dinesh Kumar Patel
Published: (2022-09-01)

Role of oxytocin in bone
by: Tianming Wang, et al.
Published: (2024-09-01)

Spatial regulation of chrysosplenetin on amino acid homeostasis linked to artemisinin resistance in Plasmodium berghei K173 based on targeted metabolomics
by: Jinjing Xu, et al.
Published: (2025-04-01)

Porcine Mandibular Bone Marrow-Derived Mesenchymal Stem Cell (BMSC)-Derived Extracellular Vesicles Can Promote the Osteogenic Differentiation Capacity of Porcine Tibial-Derived BMSCs
by: Qun Zhao, et al.
Published: (2024-02-01)

Pentazocine Protects SN4741 Cells Against MPP+-Induced Cell Damage via Up-Regulation of the Canonical Wnt/β-Catenin Signaling Pathway
by: Jiancai Wang, et al.
Published: (2017-06-01)

Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats
by: Dandan Chen, et al.
Published: (2020-04-01)

Effects of Dickkopf-1 (DKK-1) on Prostate Cancer Growth and Bone Metastasis
by: Shiyu Yuan, et al.
Published: (2023-11-01)

Reciprocal Interferences of TNF-α and Wnt1/β-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure
by: Yueping Chen, et al.
Published: (2013-09-01)

Continuous non-adherent culture promotes transdifferentiation of human adipose-derived stem cells into retinal lineage
by: Ling Qiying, et al.
Published: (2023-11-01)

PAP Polypeptide Promotes Osteogenesis in Jaw Bone Defect Repair by Inhibiting Inflammatory Reactions
by: Ke Guo, et al.
Published: (2022-06-01)

Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease
by: Jih-Yang Ko, et al.
Published: (2024-05-01)

Blue Mussel-Derived Peptides PIISVYWK and FSVVPSPK Trigger Wnt/β-Catenin Signaling-Mediated Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells
by: Yunok Oh, et al.
Published: (2020-10-01)

Chrysosplenetin acts as a homeostasis stabilizer with dual-function in shattering Plasmodium berghei K173 resistance to artemisinin driven by both ABC transporters and heme-ROS/GSH axis
by: Hongyan Ji, et al.
Published: (2025-10-01)

The Wnt/β-catenin signaling pathway is involved in regulating feather growth of embryonic chicks
by: W.Y. Xie, et al.
Published: (2020-05-01)

Loss of inhibition over master pathways of bone mass regulation results in osteosclerotic bone metastases in prostate cancer
by: CA Rentsch, et al.
Published: (2009-04-01)

Endometrium-derived mesenchymal stem cells suppress progression of endometrial cancer via the DKK1-Wnt/β-catenin signaling pathway
by: Yuhui Xu, et al.
Published: (2023-06-01)

β-Catenin: A Key Molecule in Osteoblast Differentiation
by: Edyta Wróbel, et al.
Published: (2025-07-01)

Quercetin-loaded nanocomposite microspheres for chronologically promoting bone repair via synergistic immunoregulation and osteogenesis
by: Chunyu Han, et al.
Published: (2022-10-01)

Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway
by: Luyao Li, et al.
Published: (2022-05-01)

Highly oxidized flavones in Artemisia species – structure revisions and improved UHPLC-MSn analysis
by: Olaf Kunert, et al.
Published: (2023-11-01)

Adiponectin Deficiency Triggers Bone Loss by Up-Regulation of Osteoclastogenesis and Down-Regulation of Osteoblastogenesis
by: Jihyun Yang, et al.
Published: (2019-11-01)

Engineering 3D-BMSC exosome-based hydrogels that collaboratively regulate bone microenvironment and promote osteogenesis for enhanced cell‐free bone regeneration
by: Kai Xiang, et al.
Published: (2025-06-01)

DKK3 promotes adipogenic differentiation of stem cells by inhibiting Wnt/β-catenin signaling pathway related gene expression and mitochondrial autophagy function
by: Ze Zhang, et al.
Published: (2024-12-01)

Aqueous extract of freeze-dried Protaetia brevitarsis larvae promotes osteogenesis by activating β-catenin signaling
by: Jayasingha Arachchige Chathuranga Chanaka Jayasingha, et al.
Published: (2022-01-01)

Andrographolide Exerts Pro-Osteogenic Effect by Activation of Wnt/β-Catenin Signaling Pathway in Vitro
by: Tongmeng Jiang, et al.
Published: (2015-07-01)

Bone Substitute Effect on Vascularization and Bone Remodeling after Application of phVEGF165 Transfected BMSC
by: Michael Fehr, et al.
Published: (2012-04-01)

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
by: Dimitri Papukashvili, et al.
Published: (2021-10-01)

Inhibition of DKK2 in hepatocellular carcinoma cell lines by hepatitis B virus X protein
by: WANG Xiao-yan, DU Hong, WANG Wei, QUAN Hui-qin
Published: (2020-10-01)

Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling pathway inhibitor 2 axis
by: Yingqian Zhang, et al.
Published: (2023-02-01)

DLX3 Inhibits the Proliferation of Human Dental Pulp Cells Through Inactivation of Canonical Wnt/β-Catenin Signaling Pathway
by: Yunyan Zhan, et al.
Published: (2018-11-01)

Risperidone induces apoptosis of human osteoblast cell line hFob1.19 through Wnt/β-catenin signaling pathway
by: PANG Lan, LI Peifan, ZHENG Lei, WANG Yiming
Published: (2023-03-01)

miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/β-catenin signaling pathway
by: Xiaoguang Zhu, et al.
Published: (2018-09-01)

Micro Ribonucleic Acid−29a (miR−29a) Antagonist Normalizes Bone Metabolism in Osteogenesis Imperfecta (OI) Mice Model
by: Jih-Yang Ko, et al.
Published: (2023-02-01)

Progress of Wnt Signaling Pathway in Osteoporosis
by: Yongguang Gao, et al.
Published: (2023-03-01)

Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
by: Paria Bayati, et al.
Published: (2023-11-01)

Petroleum ether extract of Cissus quadrangularis (Linn.) enhances bone marrow mesenchymal stem cell proliferation and facilitates osteoblastogenesis
by: Bhagath Kumar Potu, et al.
Published: (2009-01-01)

The effect of low-level estrogen in mandibular bone: An in vivo study
by: Nike Hendrijanti, et al.
Published: (2019-01-01)

Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption
by: Kun Chen, et al.
Published: (2018-09-01)

Neuronal Primary Cilia Mediate Noggin Release to Enable Extracellular Signaling
by: Sara R. Dunlop, et al.
Published: (2025-10-01)