Targeting vascular disrupting agent-treated tumor microenvironment with tissue-penetrating nanotherapy

Abstract Cancer treatment with vascular disrupting agents (VDAs) causes rapid and extensive necrosis in solid tumors. However, these agents fall short in eliminating all malignant cells, ultimately leading to tumor regrowth. Here, we investigated whether the molecular changes in the tumor microenvir...

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Bibliographic Details
Published in:	Scientific Reports
Main Authors:	Valeria Sidorenko, Pablo Scodeller, Ain Uustare, Ivan Ogibalov, Andrus Tasa, Olga Tshubrik, Liis Salumäe, Kazuki N. Sugahara, Lorena Simón-Gracia, Tambet Teesalu
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-07-01
Subjects:	Vascular disrupting agent CA4P Utorubicin Tumor-penetrating peptide iRGD Polymersomes
Online Access:	https://doi.org/10.1038/s41598-024-64610-7

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