Mechanism of Proton Pumping in Complex I of the Mitochondrial Respiratory Chain

We propose a physical mechanism of conformation-induced proton pumping in mitochondrial Complex I. The structural conformations of this protein are modeled as the motion of a piston having positive charges on both sides. A negatively charged electron attracts the piston, moving the other end away fr...

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Bibliographic Details

Published in:	Quantum Reports
Main Authors:	Jonathan Friedman, Lev Mourokh, Michele Vittadello
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	mitochondrial respiratory chain proton-pumping Complex I conformation-assisted transport proton-coupled electron transfer quantum yield
Online Access:	https://www.mdpi.com/2624-960X/3/3/27