Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium
Hypereosinophilic syndrome (HES) is defined as hypereosinophilia due to any cause (absolute eosinophil count > 1500 cells/μL) in the peripheral blood, which leads to eosinophil-mediated multiorgan damage. Cardiac involvement is a significant cause of morbidity and mortality among patients with HE...
| 出版年: | Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging |
|---|---|
| 主要な著者: | , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| 主題: | |
| オンライン･アクセス: | https://journals.lww.com/10.4103/jiae.jiae_43_24 |
| _version_ | 1849549429841854464 |
|---|---|
| author | Ajay Sinha Pramod Kumar Saket Sharma Shraddha Ranjan |
| author_facet | Ajay Sinha Pramod Kumar Saket Sharma Shraddha Ranjan |
| author_sort | Ajay Sinha |
| collection | DOAJ |
| container_title | Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging |
| description | Hypereosinophilic syndrome (HES) is defined as hypereosinophilia due to any cause (absolute eosinophil count > 1500 cells/μL) in the peripheral blood, which leads to eosinophil-mediated multiorgan damage. Cardiac involvement is a significant cause of morbidity and mortality among patients with HES. Here, we discuss a case of eosinophilia-related endomyocardial involvement, also known as Loeffler’s endocarditis, a rare form of restrictive cardiomyopathy. Notably, on genetic analysis, he was found to have a rare FIP1-like-1-platelet-derived growth factor receptor alpha-associated myeloproliferative variant of HES, which responded to imatinib, making it one of the very few reported cases of such kind. |
| format | Article |
| id | doaj-art-c33b3db87fdd4e7a98e5e41347297a7d |
| institution | Directory of Open Access Journals |
| issn | 2543-1463 2543-1471 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| spelling | doaj-art-c33b3db87fdd4e7a98e5e41347297a7d2025-08-20T02:40:20ZengWolters Kluwer Medknow PublicationsJournal of the Indian Academy of Echocardiography & Cardiovascular Imaging2543-14632543-14712024-12-018320120510.4103/jiae.jiae_43_24Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the EndocardiumAjay SinhaPramod KumarSaket SharmaShraddha RanjanHypereosinophilic syndrome (HES) is defined as hypereosinophilia due to any cause (absolute eosinophil count > 1500 cells/μL) in the peripheral blood, which leads to eosinophil-mediated multiorgan damage. Cardiac involvement is a significant cause of morbidity and mortality among patients with HES. Here, we discuss a case of eosinophilia-related endomyocardial involvement, also known as Loeffler’s endocarditis, a rare form of restrictive cardiomyopathy. Notably, on genetic analysis, he was found to have a rare FIP1-like-1-platelet-derived growth factor receptor alpha-associated myeloproliferative variant of HES, which responded to imatinib, making it one of the very few reported cases of such kind.https://journals.lww.com/10.4103/jiae.jiae_43_24eosinophiliafip1-like-1-platelet-derived growth factor receptor alphahypereosinophilic syndromeloeffler’s endocarditisparasitic infectionsrestrictive cardiomyopathy |
| spellingShingle | Ajay Sinha Pramod Kumar Saket Sharma Shraddha Ranjan Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium eosinophilia fip1-like-1-platelet-derived growth factor receptor alpha hypereosinophilic syndrome loeffler’s endocarditis parasitic infections restrictive cardiomyopathy |
| title | Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium |
| title_full | Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium |
| title_fullStr | Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium |
| title_full_unstemmed | Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium |
| title_short | Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium |
| title_sort | loeffler s endocarditis unforgiving eosinophilic damage to the endocardium |
| topic | eosinophilia fip1-like-1-platelet-derived growth factor receptor alpha hypereosinophilic syndrome loeffler’s endocarditis parasitic infections restrictive cardiomyopathy |
| url | https://journals.lww.com/10.4103/jiae.jiae_43_24 |
| work_keys_str_mv | AT ajaysinha loefflersendocarditisunforgivingeosinophilicdamagetotheendocardium AT pramodkumar loefflersendocarditisunforgivingeosinophilicdamagetotheendocardium AT saketsharma loefflersendocarditisunforgivingeosinophilicdamagetotheendocardium AT shraddharanjan loefflersendocarditisunforgivingeosinophilicdamagetotheendocardium |