Healing of Periodontal Suprabony Defects following Treatment with Open Flap Debridement with or without Hyaluronic Acid (HA) Application

• Published in: Medicina
• Main Authors: Octavia Carolina Vela, Marius Boariu, Darian Rusu, Vincenzo Iorio-Siciliano, Luca Ramaglia, Simina Boia, Viorelia Radulescu, Ioana Ilyes, Stefan-Ioan Stratul
• Format: Article
• Language: English
• Published: MDPI AG 2024-05-01
• Subjects: open flap debridement; suprabony defects; hyaluronic acid; periodontal pocket; periodontal regeneration
• Online Access: https://www.mdpi.com/1648-9144/60/5/829
• ISSN: 1010-660X; 1648-9144

<i>Background and Objectives:</i> This randomized, double-arm, multicentric clinical trial aims to compare the clinical outcomes following the treatment of suprabony periodontal defects using open flap debridement (OFD) with or without the application of hyaluronic acid (HA). <i>Materials and Methods:</i> Sixty systemically healthy patients with at least two teeth presenting suprabony periodontal defects were randomly assigned with a 1:1 allocation ratio using computer-generated tables into a test (OFD + HA) or control group (OFD). The main outcome variable was clinical attachment level (CAL). The secondary outcome variables were changes in mean probing pocket depth (PPD), gingival recession (GR), full-mouth plaque score (FMPS), and full-mouth bleeding score (FMBS). All clinical measurements were carried out at baseline and 12 months. <i>Results:</i> Sixty patients, thirty in each group, were available for statistical analysis. The mean CAL gain was statistically significantly different (<i>p</i> < 0.001) in the test group compared with the control group (3.06 ± 1.13 mm vs. 1.44 ± 1.07 mm). PPD reduction of test group measurements (3.28 ± 1.14 mm) versus the control group measurements (2.61 ± 1.22 mm) were statistically significant (<i>p</i> = 0.032). GR changes were statistically significant only in the test group 0.74 ± 1.03 mm (<i>p</i> < 0.001). FMBS and FMPS revealed a statistically significant improvement mostly in the test group. <i>Conclusions:</i> Suprabony periodontal defects could benefit from the additional application of HA in conjunction with OFD in terms of improvement of the clinical parameters compared with OFD alone.