Therapeutic Effects of Fire Needling Acupuncture on Pain Relief and Cartilage Protection in MIA-Induced Knee Osteoarthritis Rats: The Role of Macrophage Polarization in Synovium and Angiogenesis in Subchondral Bone

Jiangyan Wei,1,&ast; Xin Yang,1,&ast; Xiaobo Ge,2,&ast; Luopeng Zhao,3 Xueyan Liu,1,2 Jiarun Zhang,1 Jun Zhou,1 Chengcheng Zhang,1 Wenshan Li,1,2 Zhijuan Li,1 Tianli Lyu,1 Yizhan Wang,1 Fang Yuan,1 Lu Liu,1 Bin Li1 1Department of Acupuncture and Moxibustion, Beijing Hospital...

Full description

Bibliographic Details
Published in:	Journal of Inflammation Research
Main Authors:	Wei J, Yang X, Ge X, Zhao L, Liu X, Zhang J, Zhou J, Zhang C, Li W, Li Z, Lyu T, Wang Y, Yuan F, Liu L, Li B
Format:	Article
Language:	English
Published:	Dove Medical Press 2025-06-01
Subjects:	fire needling acupuncture knee osteoarthritis cartilage degradation macrophages polarization subchondral bone angiogenesis
Online Access:	https://www.dovepress.com/therapeutic-effects-of-fire-needling-acupuncture-on-pain-relief-and-ca-peer-reviewed-fulltext-article-JIR

Similar Items

Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium
by: Xiaoshan Gong, et al.
Published: (2024-12-01)

Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone
by: Wang Yajun, et al.
Published: (2021-09-01)

Simvastatin retards cartilage degradation and subchondral bone deterioration induced by a high-fat diet in mice
by: Hetong Li, et al.
Published: (2023-12-01)

Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis
by: Shao-Hua Ping, et al.
Published: (2022-10-01)

Osteoarthritic Subchondral Bone Release Exosomes That Promote Cartilage Degeneration
by: Xiaoxin Wu, et al.
Published: (2021-01-01)

Different effects of abnormal mechanical stress on temporomandibular joint cartilage, subchondral bone, and discs
by: Miao Xiao, et al.
Published: (2025-04-01)

Endothelium-dependent molecular mechanisms of articular cartilage and subchondral bone remodeling in conditions of cardiovascular comorbidity
by: M. A. Kabalyk, et al.
Published: (2019-11-01)

Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial
by: Ville-Markus Konola, et al.
Published: (2025-06-01)

Subchondral bone proteomics in osteoarthritis: Current status and perspectives
by: Pok Man Boris Chan, et al.
Published: (2015-04-01)

Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice
by: Guoqing Li, et al.
Published: (2023-01-01)

Diallyl disulfide knee joint injection protects against the early pathologic changes of articular cartilage and subchondral bone in ovariectomized rats
by: Qizhao Tan, et al.
Published: (2025-02-01)

Articular cartilage degeneration and aberrant osteocyte perilacunar/canalicular remodeling in subchondral bone of patients with developmental dysplasia of the hip
by: Teng Ye, et al.
Published: (2025-02-01)

Hypoxia-induced Wnt/β-catenin signaling activation in subchondral bone osteoblasts leads to an osteoarthritis-like phenotype of chondrocytes in articular cartilage
by: Fang Li, et al.
Published: (2023-04-01)

Remodeling of articular cartilage and subchondral zone of the tibia in exo‑prosthetics of the limb
by: Tatyana A. Stupina, et al.
Published: (2025-06-01)

New role of calcium‐binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone
by: Mingshu Cui, et al.
Published: (2024-11-01)

Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study
by: Yibao Wei, et al.
Published: (2024-06-01)

Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed
by: Chunyi Wen, et al.
Published: (2014-01-01)

The Possibilities of Magnetic Resonance Imaging in the Diagnosis of Microstructural Changes of the Subchondral Bone in Osteoarthritis
by: M. A. Kabalyk
Published: (2019-01-01)

Developing a deep learning model for the automated monitoring of acupuncture needle insertion: enhancing safety in traditional acupuncture practices
by: Shun-Ku Lin, et al.
Published: (2025-03-01)

Subchondral bone: An emerging target for the treatment of articular surface lesions of the knee
by: Alessandro Sangiorgio, et al.
Published: (2024-07-01)

Bone marrow lesion coexisted with subchondral bone attrition and/or subchondral bone cyst is associated with knee pain in knee osteoarthritis regardless of cartilage lesion: the Bunkyo health study
by: Jun Tomura, et al.
Published: (2025-09-01)

Human osteoarthritic articular cartilage stem cells suppress osteoclasts and improve subchondral bone remodeling in experimental knee osteoarthritis partially by releasing TNFAIP3
by: Zhi-Ling Li, et al.
Published: (2023-09-01)

Subchondral Bone Microarchitectural and Mineral Properties and Expression of Key Degradative Proteinases by Chondrocytes in Human Hip Osteoarthritis
by: Yunfei Li, et al.
Published: (2021-11-01)

Protective effects of tumor necrosis factor-α blockade by adalimumab on articular cartilage and subchondral bone in a rat model of osteoarthritis
by: C.H. Ma, et al.
Published: (2015-01-01)

Observation of Fine Structures of Defective Herbal Acupuncture Needles
by: Won Pil Park, et al.
Published: (2005-02-01)

Angiogenesis unveiled: Insights into its role and mechanisms in cartilage injury
by: Chenglong Wang, et al.
Published: (2024-10-01)

miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4
by: Han Tang, et al.
Published: (2022-09-01)

Enhanced Cartilage and Subchondral Bone Repair Using Carbon Nanotube-Doped Peptide Hydrogel–Polycaprolactone Composite Scaffolds
by: Jiayi Lv, et al.
Published: (2023-08-01)

Effectiveness of Filiform Needle Acupuncture and Long Needle Acupuncture in Managing Periarthritis of the Shoulder: a randomized controlled trial
by: Dong Phuong Tran, et al.
Published: (2025-06-01)

Acupuncture and dry needling for physical therapy of scar: a systematic review
by: Daria Chmielewska, et al.
Published: (2024-01-01)

Subchondral insufficiency fracture of the knee: progress in the pathogenesis and treatment
by: Ziyue Wang, et al.
Published: (2025-10-01)

Warm needle acupuncture for osteoarthritis: An overview of systematic reviews and meta-analysis
by: Ji Hee Jun, et al.
Published: (2023-03-01)

Removal of a broken acupuncture needle in retroperitoneum by laparoscopy: a case report
by: Zhen-Hua Liu, et al.
Published: (2019-08-01)

Icariin-conditioned serum combined with chitosan attenuates cartilage injury in rabbit knees with osteochondral defect
by: Juntao Zhang, et al.
Published: (2023-02-01)

Laparoscopic removal of an aberrant acupuncture needle in the gluteus that reached the pelvic cavity: a case report
by: Akira Yamamoto, et al.
Published: (2021-02-01)

The role of cells and signal pathways in subchondral bone in osteoarthritis
by: Pan Luo, et al.
Published: (2023-09-01)

Combination of a human articular cartilage-derived extracellular matrix scaffold and microfracture techniques for cartilage regeneration: A proof of concept in a sheep model
by: Liqing Peng, et al.
Published: (2024-01-01)

Avocado/Soybean Unsaponifiables (Piacledine®300) show beneficial effect on the metabolism of osteoarthritic cartilage, synovium and subchondral bone: An overview of the mechanisms
by: Yves Edgard Henrotin
Published: (2017-12-01)

Different subchondral trabecular bone microstructure and biomechanical properties between developmental dysplasia of the hip and primary osteoarthritis
by: Linyang Chu, et al.
Published: (2020-05-01)

Laparoscopic removal of a migrating acupuncture needle from the obturator muscle
by: Abdullah Al-Sawat, et al.
Published: (2021-10-01)