Propranolol-Loaded Limonene-Based Microemulsion Thermo-Responsive Mucoadhesive Nasal Nanogel: Design, In Vitro Assessment, Ex Vivo Permeation, and Brain Biodistribution

Propranolol is the first-line drug for managing migraine attacks. D-limonene is a citrus oil known for its neuroprotective mechanism. Thus, the current work aims to design a thermo-responsive intranasal limonene-based microemulsion mucoadhesive nanogel to improve propranolol efficacy. Microemulsion...

Full description

Bibliographic Details
Published in:	Gels
Main Authors:	Kawthar K. Abla, Souraya Domiati, Rania El Majzoub, Mohammed M. Mehanna
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	brain distribution BBB limonene microemulsion thermo-sensitive mucoadhesion
Online Access:	https://www.mdpi.com/2310-2861/9/6/491

Similar Items

Formulation and kinetic modeling of curcumin loaded intranasal mucoadhesive microemulsion
by: B Mikesh Patel, et al.
Published: (2012-01-01)

Microemulsions: An Encapsulation Strategy to Increase the Thermal Stability of D-limonene
by: Bruna Rodrigues Belem, et al.
Published: (2023-11-01)

Chitosan-TPP Nanogels for Ocular Delivery of Folic Acid: Release Profile, Corneal Permeation, and Mucoadhesion Assessment
by: Sebastián G. Bruno, et al.
Published: (2025-03-01)

Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting
by: Sara Meirinho, et al.
Published: (2023-06-01)

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties
by: Marija Jovanović, et al.
Published: (2021-02-01)

Mucoadhesive Marine Polysaccharides
by: Irina M. Yermak, et al.
Published: (2022-08-01)

Mucoadhesive drug delivery systems
by: Rahamatullah Shaikh, et al.
Published: (2011-01-01)

Mucoadhesive drug delivery system: An overview
by: Bindu M Boddupalli, et al.
Published: (2010-01-01)

Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson’s Disease in Rats: Formulation, Optimization, Characterization, and In Vivo Evaluation
by: Mohd Imran, et al.
Published: (2023-02-01)

Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of carbamazepine
by: Rashmin B. Patel, et al.
Published: (2013-12-01)

Cycloaddition of limonene epoxide and CO2 over Zn/SBA-15 catalysts for limonene carbonate synthesis
by: Carina Mosquera, et al.
Published: (2024-05-01)

Mucoadhesive Cationic Polypeptide Nanogel with Enhanced Penetration for Efficient Intravesical Chemotherapy of Bladder Cancer
by: Hui Guo, et al.
Published: (2018-06-01)

Buccal administration of mucoadhesive blend films saturated with propranolol loaded nanoparticles
by: Pakorn Kraisit, et al.
Published: (2018-01-01)

Synthesis of Renewable Poly(limonene): A Kinetic Modeling Study to Improve the Polymerization
by: Felipe Mourão Coelho, et al.
Published: (2020-07-01)

Microemulsion Synthesis of Nanoparticles
by: Gotić, M., et al.
Published: (2013-11-01)

Permeation Enhancer in Microemulsions and Microemulsion-Based Gels: A Comparison of Diethylene Glycol Monoethyl Ether and Oleyl Alcohol
by: Sujata Pandey, et al.
Published: (2025-01-01)

Neuroprotective Potential of Limonene and Limonene Containing Natural Products
by: Lujain Bader Eddin, et al.
Published: (2021-07-01)

Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene
by: Verginica Schroder, et al.
Published: (2022-12-01)

Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films
by: András Kelemen, et al.
Published: (2020-11-01)

Approaches to the Functionalization of Organosilicon Dendrones Based on Limonene
by: Aleksei I. Ryzhkov, et al.
Published: (2023-02-01)

Biotransformation of the monoterpene, limonene, by Fusarium verticilloides
by: Brás Heleno de Oliveira, et al.
Published: (2000-01-01)

Formulation Options for Mucoadhesive Dosage Forms for Use in the Oral Cavity
by: Šimunková V., et al.
Published: (2023-09-01)

MUCOADHESIVE GEL WITH IMMOBILIZED LYSOZYME: PREPARATION AND PROPERTIES
by: Dekina S. S., et al.
Published: (2015-08-01)

Investigation of transdermal permeation behavior of diclofenac sodium microemulsion by confocal laser scanning microscopy
by: Hui Yang, et al.
Published: (2023-04-01)

Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
by: Wu JY, et al.
Published: (2019-04-01)

Microencapsulation of limonene with polyurethane-urea and its application on cotton fabrics
by: Ekrem Talha Yilmaz, et al.
Published: (2023-12-01)

d-limonene nanoemulsion as skin permeation enhancer for curcumin prepared by ultrasonic emulsification
by: Chien-Shan Chiu, et al.
Published: (2024-03-01)

Mucoadhesive polymers in substance-based medical devices: functional ingredients or what else?
by: Barbara Vigani, et al.
Published: (2023-08-01)

The Complementary Role of ToF-SIMS in the Assessment of Imiquimod Permeated into the Skin from a Microemulsion Dosage Form
by: Mohammed Hussain Al-Mayahy, et al.
Published: (2019-12-01)

Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel
by: Abeer H. Khasraghi
Published: (2012-12-01)

Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study
by: Neha Munot, et al.
Published: (2022-10-01)

Antibacterial effect of limonene on food-borne pathogens
by: LU Haiyan, et al.
Published: (2016-05-01)

Separation of carvone by batch distillation from the mixture obtained from limonene oxidation
by: Jaime Andrés Becerra Chalá, et al.
Published: (2021-08-01)

Formulation and Evaluation of Clotrimazole Mucoadhesive Vaginal Globules
by: Barbara Jadach, et al.
Published: (2024-11-01)

Stereospecific Epoxidation of Limonene Catalyzed by Peroxygenase from Oat Seeds
by: Daniela Maria Biondi, et al.
Published: (2021-09-01)

Microemulsion-Based Keratin–Chitosan Gel for Improvement of Skin Permeation/Retention and Activity of Curcumin
by: Jiangxiu Niu, et al.
Published: (2023-07-01)

In Vitro Antimicrobial and Antibiofilm Activity of S-(-)-Limonene and R-(+)-Limonene against Fish Bacteria
by: Elisia Gomes da Silva, et al.
Published: (2021-08-01)

The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations
by: Margherita Falavigna, et al.
Published: (2020-06-01)

Novel Mucoadhesive Chitosomes as a Platform for Enhanced Oral Bioavailability of Cinnarizine
by: Oransa HA, et al.
Published: (2022-11-01)

Preparation and Characterization of Vegetable Oil-Based Microemulsions
by: Cristina Scomoroscenco, et al.
Published: (2019-10-01)