Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes
Mesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot....
| Published in: | Frontiers in Cell and Developmental Biology |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-08-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1446050/full |
| _version_ | 1849512093651304448 |
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| author | Haitao Zhuo Yunfei Chen Guifang Zhao |
| author_facet | Haitao Zhuo Yunfei Chen Guifang Zhao |
| author_sort | Haitao Zhuo |
| collection | DOAJ |
| container_title | Frontiers in Cell and Developmental Biology |
| description | Mesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot. Many previous studies have shown the role and underlying regulatory mechanisms of hypoxic preconditioning in various diseases, which has provided sufficient reference materials for the MSC research field. Therefore, this review summarizes the progress in application of hypoxia-preconditioned MSC-derived exosomes that substantially increases and improves the biological activity of specific molecules, such as microRNA. |
| format | Article |
| id | doaj-art-c6f181e9b73c4e0286559d78a00aadae |
| institution | Directory of Open Access Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-c6f181e9b73c4e0286559d78a00aadae2025-08-20T02:57:13ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-08-011210.3389/fcell.2024.14460501446050Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomesHaitao Zhuo0Yunfei Chen1Guifang Zhao2The Affiliated Qingyuan Hospital (Qingyuan People’s Hospital), Guangzhou Medical University, Qingyuan, ChinaDepartment of Nuroscience, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Pathology, Jilin Medical University, Jilin, ChinaMesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot. Many previous studies have shown the role and underlying regulatory mechanisms of hypoxic preconditioning in various diseases, which has provided sufficient reference materials for the MSC research field. Therefore, this review summarizes the progress in application of hypoxia-preconditioned MSC-derived exosomes that substantially increases and improves the biological activity of specific molecules, such as microRNA.https://www.frontiersin.org/articles/10.3389/fcell.2024.1446050/fullhypoxic preconditioningmesenchymal stem cellsexosomesmicroRNAmolecular mechanism |
| spellingShingle | Haitao Zhuo Yunfei Chen Guifang Zhao Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes hypoxic preconditioning mesenchymal stem cells exosomes microRNA molecular mechanism |
| title | Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes |
| title_full | Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes |
| title_fullStr | Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes |
| title_full_unstemmed | Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes |
| title_short | Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes |
| title_sort | advances in application of hypoxia preconditioned mesenchymal stem cell derived exosomes |
| topic | hypoxic preconditioning mesenchymal stem cells exosomes microRNA molecular mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1446050/full |
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