Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer

Phosphoinositides, a small group of lipids found in all cellular membranes, have recently garnered heightened attention due to their crucial roles in diverse biological processes and different diseases. Among these, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), the most abundant bis-phosphoryla...

Full description

Bibliographic Details
Published in:	Frontiers in Oncology
Main Authors:	Yue Jin, Jian Xue
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Subjects:	breast cancer phosphoinositide PI(4,5)P2 phosphatidylinositol phosphate kinase PIP5K PIP4K
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1323897/full

Similar Items

Downregulation of PIP4K2C inhibits the breast cancer cell proliferation, migration and invasion
by: Yue Jin, et al.
Published: (2025-07-01)

Inositol and PIP2/PIP3 Ratio: At the Crossroad of the Biodynamic Interface Between Cells and Their Microenvironment
by: Guglielmo Lentini, et al.
Published: (2025-03-01)

Implicates of PIP5K1α in asthma-related biological processes: insights into mechanisms and therapeutic potential
by: Si-Jia Wang, et al.
Published: (2025-09-01)

25 Years of PI5P
by: Lucia E. Rameh, et al.
Published: (2023-10-01)

Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1
by: Truc Phan Hoang Le, et al.
Published: (2023-06-01)

WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway–Mowat Syndrome
by: Hongyan Li, et al.
Published: (2022-09-01)

Structure–Activity Relationship Study of 3-Alkynyl-6-aryl-isothiazolo[4,3-<i>b</i>]pyridines as Dual Inhibitors of the Lipid Kinases PIKfyve and PIP4K2C
by: Demian Kalebic, et al.
Published: (2025-09-01)

MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib
by: Katharina Jonas, et al.
Published: (2023-10-01)

Crucial Players for Inter-Organelle Communication: PI5P4Ks and Their Lipid Product PI-4,5-P2 Come to the Surface
by: Archna Ravi, et al.
Published: (2022-01-01)

Installing Python Modules with pip
by: Fred Gibbs
Published: (2013-05-01)

Pip5k1c expression in osteocytes regulates bone remodeling in mice
by: Sixiong Lin, et al.
Published: (2024-03-01)

Optimizing PH Domain-Based Biosensors for Improved Plasma Membrane PIP<sub>3</sub> Measurements in Mammalian Cells
by: Amir Damouni, et al.
Published: (2025-07-01)

PIP5K2A (rs10828317) polymorphism in patients with alcohol dependence and affective disorders
by: E. V. Mikhalitskaya, et al.
Published: (2021-06-01)

The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1
by: Jamal M. Bryant, et al.
Published: (2021-01-01)

Genome-wide identification of PIP5K in wheat and its relationship with anther male sterility induced by high temperature
by: Hongzhan Liu, et al.
Published: (2021-12-01)

Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure
by: Guan Huang, et al.
Published: (2022-01-01)

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma
by: Mengzhou Guo, et al.
Published: (2025-08-01)

Structure and functional divergence of PIP peptide family revealed by functional studies on PIP1 and PIP2 in Arabidopsis thaliana
by: Xiao-song Yu, et al.
Published: (2023-11-01)

Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre‐mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis
by: Dan Nie, et al.
Published: (2024-02-01)

Conserved RNA Binding Activity of Phosphatidyl Inositol 5-Phosphate 4-Kinase (PIP4K2A)
by: Jatin Behari, et al.
Published: (2021-05-01)

Type of course of schizophrenia and polymorphisms of neuronal protein kinase genes on the model of PIP5K2A, GSK3B and AKT1
by: E. G. Poltavskaya, et al.
Published: (2019-12-01)

Novel PIP5K1C variant identified in a Chinese pedigree with lethal congenital contractural syndrome 3
by: Fang Zhang, et al.
Published: (2024-03-01)

Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer
by: Julius Semenas, et al.
Published: (2021-04-01)

Selective Termination of Autophagy-Dependent Cancers
by: Ajit Roy, et al.
Published: (2024-06-01)

Cholesterol Regulation of PIP2: Why Cell Type is So Important
by: Domenico M. Taglieri, et al.
Published: (2013-01-01)

NMR Structure of the Myristylated Feline Immunodeficiency Virus Matrix Protein
by: Lola A. Brown, et al.
Published: (2015-04-01)

Genome-Wide Characterization of the Aquaporin Gene Family in Radish and Functional Analysis of RsPIP2-6 Involved in Salt Stress
by: Xiaofang Yi, et al.
Published: (2022-07-01)

An interesting case of PIP joint fracture of Index finger
by: Boris Matev, et al.
Published: (2024-07-01)

Skin deep: Cutaneous manifestation of PIP implant rupture
by: Máire-Caitlín Casey, et al.
Published: (2021-09-01)

Differential Effects of Phosphatidylinositol 4-Kinase (PI4K) and 3-Kinase (PI3K) Inhibitors on Stomatal Responses to Environmental Signals
by: Koh Iba, et al.
Published: (2017-05-01)

CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis
by: Yan Ma, et al.
Published: (2020-03-01)

A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P<sub>2</sub>
by: Ana Bura, et al.
Published: (2023-05-01)

“Pip is my story”
by: Colomba, Caterina
Published: (2017-12-01)

Study of the polymorphic variants of the PIP5K2A gene association with the comorbidity of alcoholism and affective disorders
by: E. V. Mikhalitskaya, et al.
Published: (2019-12-01)

Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression
by: Jiayan Yan, et al.
Published: (2019-09-01)

Soluble VCAM-1 Alters Lipid Phosphatase Activity in Epicardial Mesothelial Cells: Implications for Lipid Signaling During Epicardial Formation
by: Robert W. Dettman, et al.
Published: (2013-09-01)

Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention
by: Alicia Llorente, et al.
Published: (2023-10-01)

Acute pancreatitis prevalence in children with cystic fibrosis and PIP score prediction applicability
by: Valentina-Daniela COMĂNICI, et al.
Published: (2021-06-01)

Coordinated Localization and Antagonistic Function of NtPLC3 and PI4P 5-Kinases in the Subapical Plasma Membrane of Tobacco Pollen Tubes
by: Irene Stenzel, et al.
Published: (2020-04-01)

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome
by: Martin Sztacho, et al.
Published: (2021-01-01)