Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma
Abstract Vorasidenib, an oral dual inhibitor targeting mutant enzymes isocitrate dehydrogenase 1 and 2, is utilized in the management of diffuse low-grade gliomas. Despite limited documentation of its adverse events, we present the case of a 44-year-old male who exhibited trichomegaly and hypertrich...
| الحاوية / القاعدة: | Dermatology and Therapy |
|---|---|
| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Adis, Springer Healthcare
2024-08-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1007/s13555-024-01263-4 |
| _version_ | 1850353413101977600 |
|---|---|
| author | Michela Starace Stephano Cedirian Luca Rapparini Francesca Bruni Bianca Maria Piraccini |
| author_facet | Michela Starace Stephano Cedirian Luca Rapparini Francesca Bruni Bianca Maria Piraccini |
| author_sort | Michela Starace |
| collection | DOAJ |
| container_title | Dermatology and Therapy |
| description | Abstract Vorasidenib, an oral dual inhibitor targeting mutant enzymes isocitrate dehydrogenase 1 and 2, is utilized in the management of diffuse low-grade gliomas. Despite limited documentation of its adverse events, we present the case of a 44-year-old male who exhibited trichomegaly and hypertrichosis of body hair, eyebrows, and eyelashes following one month of vorasidenib treatment. Notably, the patient experienced diffuse hair regrowth on the scalp, including in areas affected by severe androgenetic alopecia. This report holds significance as it highlights a previously unreported side effect, thereby enhancing our understanding of emerging therapies for brain tumors and their associated adverse reactions. |
| format | Article |
| id | doaj-art-c7bf2ed20bcd4a07948a7bd876243549 |
| institution | Directory of Open Access Journals |
| issn | 2193-8210 2190-9172 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| spelling | doaj-art-c7bf2ed20bcd4a07948a7bd8762435492025-08-19T23:08:32ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722024-08-0114102917292110.1007/s13555-024-01263-4Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse AstrocytomaMichela Starace0Stephano Cedirian1Luca Rapparini2Francesca Bruni3Bianca Maria Piraccini4Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di BolognaDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di BolognaDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di BolognaDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di BolognaDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di BolognaAbstract Vorasidenib, an oral dual inhibitor targeting mutant enzymes isocitrate dehydrogenase 1 and 2, is utilized in the management of diffuse low-grade gliomas. Despite limited documentation of its adverse events, we present the case of a 44-year-old male who exhibited trichomegaly and hypertrichosis of body hair, eyebrows, and eyelashes following one month of vorasidenib treatment. Notably, the patient experienced diffuse hair regrowth on the scalp, including in areas affected by severe androgenetic alopecia. This report holds significance as it highlights a previously unreported side effect, thereby enhancing our understanding of emerging therapies for brain tumors and their associated adverse reactions.https://doi.org/10.1007/s13555-024-01263-4VorasidenibTrichomegalyHypertrichosisOncology therapyAstrocytomaSide effect |
| spellingShingle | Michela Starace Stephano Cedirian Luca Rapparini Francesca Bruni Bianca Maria Piraccini Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma Vorasidenib Trichomegaly Hypertrichosis Oncology therapy Astrocytoma Side effect |
| title | Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma |
| title_full | Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma |
| title_fullStr | Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma |
| title_full_unstemmed | Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma |
| title_short | Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma |
| title_sort | vorasidenib induced trichomegaly and hypertrichosis a new side effect in a patient with diffuse astrocytoma |
| topic | Vorasidenib Trichomegaly Hypertrichosis Oncology therapy Astrocytoma Side effect |
| url | https://doi.org/10.1007/s13555-024-01263-4 |
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