Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases

The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cyt...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Hui Zhi, Hui Fu, Yunxin Zhang, Ni Fan, Chengcheng Zhao, Yunfei Li, Yujiao Sun, Yingpeng Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Subjects:	cGAS-STING pathway traditional Chinese medicine immunity disease cancer infection6 cGAS-STING pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510628/full

Similar Items

The cGAS-STING pathway in atherosclerosis
by: Si-yu Wang, et al.
Published: (2025-04-01)

Correction: The cGAS-STING pathway in atherosclerosis
by: Si-yu Wang, et al.
Published: (2025-06-01)

cGAS-STING pathway in pathogenesis and treatment of osteoarthritis and rheumatoid arthritis
by: XiCheng Yang, et al.
Published: (2024-05-01)

The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities?
by: Jun Hu, et al.
Published: (2024-12-01)

The cGAS/STING Pathway: Friend or Foe in Regulating Cardiomyopathy
by: Weiyue Wang, et al.
Published: (2025-05-01)

The cGAS-STING pathway in COPD: targeting its role and therapeutic potential
by: Kexin Liao, et al.
Published: (2024-08-01)

CMPK2 promotes microglial activation through the cGAS-STING pathway in the neuroinflammatory mechanism
by: Feng Gao, et al.
Published: (2025-04-01)

Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy
by: Kewang Luo, et al.
Published: (2022-07-01)

The role of cGAS-STING signaling in rheumatoid arthritis: from pathogenesis to therapeutic targets
by: Qiugang Zhu, et al.
Published: (2024-09-01)

FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS–STING pathway activation
by: Yijia Wu, et al.
Published: (2024-03-01)

Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis
by: Nengwen Xia, et al.
Published: (2022-10-01)

The regulation of cGAS-STING signaling by RNA virus-derived components
by: Feiting Xie, et al.
Published: (2024-05-01)

Targeting the interplay of cGAS-STING and ferroptosis by nanomedicine in the treatment of cancer
by: Chunfei Li, et al.
Published: (2025-08-01)

Advances in nanomaterials for enhancing cGAS-STING pathway mediated anti-tumor treatment
by: Ruicheng Wu, et al.
Published: (2025-10-01)

Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation
by: Ziting Xu, et al.
Published: (2025-07-01)

cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives
by: Huayu Li, et al.
Published: (2025-10-01)

Chicken DNA Sensing cGAS-STING Signal Pathway Mediates Broad Spectrum Antiviral Functions
by: Shuangjie Li, et al.
Published: (2020-07-01)

The role and mechanism of the cGAS–STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure
by: Zhimin Zhang, et al.
Published: (2025-09-01)

cGAS-STING targeting offers therapy choice in lung diseases
by: Yu Wang, et al.
Published: (2025-02-01)

cGAS-STING Targeting Offers Novel Therapeutic Opportunities in Liver Diseases
by: Wang Y, et al.
Published: (2025-07-01)

Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy
by: Xi Chen, et al.
Published: (2024-01-01)

Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms
by: Nengwen Xia, et al.
Published: (2025-12-01)

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics
by: Tangxin Zhang, et al.
Published: (2023-04-01)

Ciprofloxacin Exerts Anti-Tumor Effects In Vivo Through cGAS-STING Activation and Modulates Tumor Microenvironment
by: Jian-Syun Chen, et al.
Published: (2025-07-01)

Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway
by: Congyang Zheng, et al.
Published: (2024-09-01)

The cGAS-STING Pathway: A Promising Immunotherapy Target
by: Liang Ou, et al.
Published: (2021-12-01)

Targeting cGAS-STING signaling: a potential therapeutic approach for the management of Huntington's disease
by: Vishal Kumar, et al.
Published: (2025-01-01)

The role of cGAS-STING signaling pathway in ferroptosis
by: Lina Ding, et al.
Published: (2025-10-01)

C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS‐STING Pathway
by: Yue Wang, et al.
Published: (2025-01-01)

The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential
by: Jing Zhang, et al.
Published: (2023-10-01)

Crosstalk between cGAS-STING pathway and autophagy in cancer immunity
by: Qijun Lu, et al.
Published: (2023-03-01)

Agonists and Inhibitors of the cGAS-STING Pathway
by: Xiaoxuan Yu, et al.
Published: (2024-06-01)

Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis
by: Wei Xie, et al.
Published: (2024-05-01)

Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages
by: Stoyan Tankov, et al.
Published: (2024-02-01)

Novel insight into cGAS-STING pathway in ischemic stroke: from pre- to post-disease
by: Xiaoqi Ma, et al.
Published: (2023-10-01)

cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products
by: Dan Long, et al.
Published: (2025-06-01)

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications
by: Mengzhou Shen, et al.
Published: (2025-04-01)

Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway
by: Guojin Wu, et al.
Published: (2024-05-01)

Nucleic Acid Diversity in cGAS-STING Pathway Activation and Immune Dysregulation
by: Jingwei Guo, et al.
Published: (2025-09-01)

Advances in understanding the role and mechanism of the cGAS-STING signaling pathway in ocular diseases
by: MengDi Zhang, et al.
Published: (2025-03-01)