Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

Abstract Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines. Caspase‐1 also drives pyroptosis, a lytic cell d...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	EMBO Molecular Medicine
المؤلفون الرئيسيون:	Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Springer Nature 2022-04-01
الموضوعات:	arthritis extracellular inflammasomes gout nanobodies pyroptosis
الوصول للمادة أونلاين:	https://doi.org/10.15252/emmm.202115415

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