Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib...

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Bibliographic Details
Published in:Acta Cirúrgica Brasileira
Main Authors: José Pedro Calistro Neto, Rômulo da Costa Torres, Giovanna Maria Gonçalves, Leopoldo Muniz da Silva, Maria Aparecida Custódio Domingues, Norma Sueli Pinheiro Módolo, Guilherme Antonio Moreira de Barros
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2015-04-01
Subjects:
Parecoxib
Ischemia
Reperfusion
Kidney
Rats
Online Access:http://www.scielo.br/pdf/acb/v30n4/0102-8650-acb-30-04-00270.pdf
Description
Summary:PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.
ISSN:0102-8650

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