A Proof of Principle 2D Spatial Proteome Mapping Analysis Reveals Distinct Regional Differences in the Cardiac Proteome

Proteomics studies often explore phenotypic differences between whole organs and systems. Within the heart, more subtle variation exists. To date, differences in the underlying proteome are only described between whole cardiac chambers. This study, using the bovine heart as a model, investigates int...

Full description

Bibliographic Details
Published in:	Life
Main Authors:	Wendy E. Heywood, Jon Searle, Richard Collis, Ivan Doykov, Michael Ashworth, Neil Sebire, Andrew Bamber, Mathias Gautel, Simon Eaton, Caroline J. Coats, Perry M. Elliott, Kevin Mills
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Subjects:	heart proteome mitochondria desmoglein-2 proteomics
Online Access:	https://www.mdpi.com/2075-1729/14/8/970

Similar Items

Exploring the HeLa Dark Mitochondrial Proteome
by: Federica Marini, et al.
Published: (2020-03-01)

Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture
by: Laura C. Graham, et al.
Published: (2017-10-01)

Proteomics
by: S. Dolomatov, et al.
Published: (2021-12-01)

Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability
by: Laura C. Graham, et al.
Published: (2021-12-01)

DIA-MS Based Proteomics Combined with RNA-Seq Data to Unveil the Mitochondrial Dysfunction in Human Glioblastoma
by: Hao-Long Zeng, et al.
Published: (2023-02-01)

Proteomic profiling of mesenchymal stem cell‐derived extracellular vesicles: Impact of isolation methods on protein cargo
by: Morteza Abyadeh, et al.
Published: (2024-06-01)

Central Nervous System Proteomics in Animal Model of Multiple Sclerosis Revealed Down-Regulation of Mithochondrial Proteins
by: Abolhassan Shahzadeh Fazeli, et al.
Published: (2009-01-01)

Mitochondrial Disruption by Amyloid Beta 42 Identified by Proteomics and Pathway Mapping
by: Patricia Sinclair, et al.
Published: (2021-09-01)

Quantitative Proteomics and Network Analysis of Differentially Expressed Proteins in Proteomes of Icefish Muscle Mitochondria Compared with Closely Related Red-Blooded Species
by: Gunjan Katyal, et al.
Published: (2022-07-01)

Proteomic analysis enables distinction of early‐ versus advanced‐stage lung adenocarcinomas
by: Olga Kelemen, et al.
Published: (2020-06-01)

Proteomics of the Spermatozoon
by: Ballescá Jl, et al.
Published: (2012-12-01)

A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance
by: Luke S Tain, et al.
Published: (2017-09-01)

Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy
by: Yang Liu, et al.
Published: (2025-12-01)

The effect of Nrf2 deletion on the proteomic signature in a human colorectal cancer cell line
by: Omid Cheraghi, et al.
Published: (2022-09-01)

Proteomics Landscape of Alzheimer’s Disease
by: Ankit P. Jain, et al.
Published: (2021-03-01)

The Proteomic Landscape of Parkin-Deficient and Parkin-Overexpressing Rat Nucleus Accumbens: An Insight into the Role of Parkin in Methamphetamine Use Disorder
by: Akhil Sharma, et al.
Published: (2025-07-01)

Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation
by: Qin Gong, et al.
Published: (2019-12-01)

Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments
by: Cecilie Bo Hansen, et al.
Published: (2025-03-01)

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
by: Ceereena Ubaida-Mohien, et al.
Published: (2019-10-01)

Proteomic Analysis Reveals a Mitochondrial Remodeling of βTC3 Cells in Response to Nanotopography
by: Elisa Maffioli, et al.
Published: (2020-07-01)

Glioblastoma survival is associated with distinct proteomic alteration signatures post chemoirradiation in a large-scale proteomic panel
by: Andra Valentina Krauze, et al.
Published: (2023-08-01)

Mitochondrial Proteome Changes in Rett Syndrome
by: Gocha Golubiani, et al.
Published: (2023-07-01)

Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions
by: Giorgio Oliviero, et al.
Published: (2022-03-01)

Proteomics in thrombosis research
by: Fredrik Edfors, et al.
Published: (2022-03-01)

Corrigendum: Glioblastoma survival is associated with distinct proteomic alteration signatures post chemoirradiation in a large-scale proteomic panel
by: Andra Valentina Krauze, et al.
Published: (2024-03-01)

Standard Flow Multiplexed Proteomics (SFloMPro)—An Accessible Alternative to NanoFlow Based Shotgun Proteomics
by: Benjamin C. Orsburn, et al.
Published: (2022-01-01)

Mitochondrial Proteome Reveals Metabolic Tuning by Restricted Insulin Signaling to Promote Longevity in <i>Caenorhabditis elegans</i>
by: Xuanxuan Guo, et al.
Published: (2025-03-01)

Welfare Assessment in Pigs Using the Salivary Proteome
by: Sara Prims, et al.
Published: (2024-06-01)

Proteomic profiling of IgA nephropathy reveals distinct molecular prognostic subtypes
by: Xizhao Chen, et al.
Published: (2023-03-01)

Molecular composition of skeletal muscle in infants and adults: a comparative proteomic and transcriptomic study
by: Alexander Schaiter, et al.
Published: (2024-10-01)

HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis
by: Cagla Cömert, et al.
Published: (2024-10-01)

The Mitochondrial Proteome of Tumor Cells: A SnapShot on Methodological Approaches and New Biomarkers
by: Loredana Moro
Published: (2020-12-01)

Proteomic Case Studies of MDS in Progression: Heterogeneity and More Heterogeneity
by: Klara Pecankova, et al.
Published: (2022-11-01)

Proteomic Advances in Milk and Dairy Products
by: Rubén Agregán, et al.
Published: (2021-06-01)

Proteomic Signatures of Hippocampal Nonsynaptic and Synaptosome-Enriched Mitochondria in Rats Resilient to Chronic Social Isolation
by: Dragana Filipović, et al.
Published: (2025-09-01)

Proteomic biomarkers of depression
by: Tang Li, et al.
Published: (2022-04-01)

BIOMEDICAL ENGINEERING AND PROTEOMICS
by: Marianna Trebuňová, et al.
Published: (2018-03-01)

Proteomics: taking over where genomics leaves off
by: Ritu MAHAJAN, et al.
Published: (2010-06-01)

Proteomic investigations of complex I composition: How to define a subunit?
by: Etienne H Meyer
Published: (2012-05-01)

Recent Developments in Clinical Plasma Proteomics—Applied to Cardiovascular Research
by: Nicolai Bjødstrup Palstrøm, et al.
Published: (2022-01-01)