Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris
Pemphigus vulgaris (PV) is an IgG autoantibody-mediated, potentially fatal mucocutaneous disease manifested by progressive non-healing erosions and blisters. Beyond acting to inhibit adhesion molecules, PVIgGs elicit a unique process of programmed cell death and detachment of epidermal keratinocytes...
| Published in: | Antibodies |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4468/11/3/55 |
| _version_ | 1850102109362454528 |
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| author | Dana M. Hutchison Anna-Marie Hosking Ellen M. Hong Sergei A. Grando |
| author_facet | Dana M. Hutchison Anna-Marie Hosking Ellen M. Hong Sergei A. Grando |
| author_sort | Dana M. Hutchison |
| collection | DOAJ |
| container_title | Antibodies |
| description | Pemphigus vulgaris (PV) is an IgG autoantibody-mediated, potentially fatal mucocutaneous disease manifested by progressive non-healing erosions and blisters. Beyond acting to inhibit adhesion molecules, PVIgGs elicit a unique process of programmed cell death and detachment of epidermal keratinocytes termed apoptolysis. Mitochondrial damage by antimitochondrial antibodies (AMA) has proven to be a critical link in this process. AMA act synergistically with other autoantibodies in the pathogenesis of PV. Importantly, absorption of AMA inhibits the ability of PVIgGs to induce blisters. Pharmacologic agents that protect mitochondrial function offer a new targeted approach to treating this severe immunoblistering disease. |
| format | Article |
| id | doaj-art-c8a8ac6820b94cc7bbcbfb35bc71b71e |
| institution | Directory of Open Access Journals |
| issn | 2073-4468 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-c8a8ac6820b94cc7bbcbfb35bc71b71e2025-08-20T00:04:08ZengMDPI AGAntibodies2073-44682022-08-011135510.3390/antib11030055Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus VulgarisDana M. Hutchison0Anna-Marie Hosking1Ellen M. Hong2Sergei A. Grando3Department of Dermatology, University of California Irvine, Irvine, CA 92697, USADepartment of Dermatology, University of California Irvine, Irvine, CA 92697, USABeckman Laser Institute, University of California Irvine, Irvine, CA 92612, USADepartment of Dermatology, University of California Irvine, Irvine, CA 92697, USAPemphigus vulgaris (PV) is an IgG autoantibody-mediated, potentially fatal mucocutaneous disease manifested by progressive non-healing erosions and blisters. Beyond acting to inhibit adhesion molecules, PVIgGs elicit a unique process of programmed cell death and detachment of epidermal keratinocytes termed apoptolysis. Mitochondrial damage by antimitochondrial antibodies (AMA) has proven to be a critical link in this process. AMA act synergistically with other autoantibodies in the pathogenesis of PV. Importantly, absorption of AMA inhibits the ability of PVIgGs to induce blisters. Pharmacologic agents that protect mitochondrial function offer a new targeted approach to treating this severe immunoblistering disease.https://www.mdpi.com/2073-4468/11/3/55pemphigus vulgarisapoptosisapoptosisantimitochondrial autoantibodies |
| spellingShingle | Dana M. Hutchison Anna-Marie Hosking Ellen M. Hong Sergei A. Grando Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris pemphigus vulgaris apoptosis apoptosis antimitochondrial autoantibodies |
| title | Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris |
| title_full | Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris |
| title_fullStr | Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris |
| title_full_unstemmed | Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris |
| title_short | Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris |
| title_sort | mitochondrial autoantibodies and the role of apoptosis in pemphigus vulgaris |
| topic | pemphigus vulgaris apoptosis apoptosis antimitochondrial autoantibodies |
| url | https://www.mdpi.com/2073-4468/11/3/55 |
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