Early immune response to Coccidioides is characterized by robust neutrophil and fibrotic macrophage recruitment and differentiation

ABSTRACT Coccidioidomycosis, or Valley fever, is an emerging respiratory disease caused by soil-dwelling fungi of the Coccidioides genus that is expected to spread from the southwest into the central U.S. by 2050. While 60% of infections are asymptomatic, the other 40% of patients experience a range...

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Bibliographic Details
Published in:Microbiology Spectrum
Main Authors: Nadia Miranda, Oscar A. Davalos, Aimy Sebastian, Margarita V. Rangel, Nicole F. Leon, Bria M. Gorman, Deepa K. Murugesh, Nicholas R. Hum, Gabriela G. Loots, Katrina K. Hoyer, Dina R. Weilhammer
Format: Article
Language:English
Published: American Society for Microbiology 2025-09-01
Subjects:
Coccidioides
scRNAseq
neutrophils
macrophages
Valley fever
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00442-25

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