A stepwise optimization strategy to formulate in situ gelling formulations comprising fluconazole-hydroxypropyl-beta-cyclodextrin complex loaded niosomal vesicles and Eudragit nanoparticles for enhanced antifungal activity and prolonged ocular delivery

Fungal keratitis and endopthalmitis are serious eye diseases. Fluconazole (FL) is indicated for their treatment, but suffers from poor topical ocular availability. This study was intended to improve and prolong its ocular availability. FL niosomal vesicles were prepared using span 60. Also, polymeri...

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Bibliographic Details
Published in:	Asian Journal of Pharmaceutical Sciences
Main Authors:	Heba Elmotasem, Ghada E.A. Awad
Format:	Article
Language:	English
Published:	Elsevier 2020-09-01
Subjects:	Fluconazole Ocular Eudragit nanoparticles Cyclodextrin Niosomes In situ gel
Online Access:	http://www.sciencedirect.com/science/article/pii/S1818087619307962

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