Assessing expression patterns of PTGR1, a potential biomarker for acylfulven sensitivity in urothelial carcinoma

Abstract Background Metastatic urothelial carcinoma (mUC) has a poor prognosis, despite recent therapeutic advancements. Prostaglandin Reductase 1 (PTGR1) is essential for activating acylfulvens, a promising class of drugs for treating a subset of urothelial carcinoma (UC) patients. The efficacy of...

Full description

Bibliographic Details
Published in:	Scientific Reports
Main Authors:	Dag Rune Stormoen, Signe Lehn, Kent W. Mouw, Zoltan Szallasi, Linea Cecilie Melchior, Line Hammer Dohn, Judit Börcsok, Maria Rossing, Birgitte Grønkaer Toft, Helle Pappot
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Subjects:	Bladder cancer Urothelial cancer Biomarker Validation study DNA repair deficiency PTGR1
Online Access:	https://doi.org/10.1038/s41598-024-79334-x

Similar Items

Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity
by: Yi-Cheng Chang, et al.
Published: (2025-03-01)

The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p
by: Du Hyeong Lee, et al.
Published: (2024-02-01)

Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma
by: Wei Chang, et al.
Published: (2025-07-01)

Corrigendum: Prostaglandin reductase 1 as a potential therapeutic target for cancer therapy
by: Xing Wang, et al.
Published: (2023-05-01)

An Exploratory Study of Early Immune Response Markers for Pembrolizumab in Urothelial Tract Cancer
by: Dag Rune Stormoen, et al.
Published: (2024-01-01)

The iBLAD study: patient-reported outcomes in bladder cancer during oncological treatment: a multicenter national randomized controlled trial
by: Gry Assam Taarnhøj, et al.
Published: (2023-10-01)

Acylfulvenes covalently interact with thioredoxin as an additional cancer target
by: Laura Slappendel, et al.
Published: (2024-09-01)

PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum.
by: Kuankuan Liu, et al.
Published: (2023-01-01)

PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum
by: Kuankuan Liu, et al.
Published: (2023-01-01)

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma
by: Aurel Prosz, et al.
Published: (2023-11-01)

An example of drug repurposing: ebastine in combination with docetaxel as a treatment for metastatic castration-resistant prostate cancer–the EXUROC prostate study, a clinical trial protocol
by: Katrine Ørum, et al.
Published: (2025-07-01)

Artificial Intelligence and Novel Technologies for the Diagnosis of Upper Tract Urothelial Carcinoma
by: Nikolaos Kostakopoulos, et al.
Published: (2025-05-01)

Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification
by: Fateme Khalatbari, et al.
Published: (2023-09-01)

Complete Response of Rare Sarcomatoid Upper Tract Urothelial Carcinoma Variant: Case Report and Literature Review
by: Syah Mirsya Warli, et al.
Published: (2023-05-01)

Case report: Toripalimab plus anlotinib in postoperative recurrent renal pelvic sarcomatoid urothelial carcinoma
by: Xinrong Hu, et al.
Published: (2024-09-01)

Author Correction: Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity
by: Yi-Cheng Chang, et al.
Published: (2025-04-01)

Expression of Vitamin D Receptor (VDR) in Urinary Bladder Carcinoma: Immunohistochemical and Histopathological Study
by: Rehab Mohamed Sharaf, et al.
Published: (2022-09-01)

Utility of reporting urine cytology samples as per the Paris system
by: Ramesh Dhakhwa, et al.
Published: (2022-03-01)

Papillary urothelial neoplasm of low malignant potential with osseous metaplasia in a 19-year-old chronic smoker: A case report with review of literature
by: Rakesh K. Gupta, et al.
Published: (2022-05-01)

Comparison of the oncological and functional outcomes among patients with high‐risk upper tract urothelial cancer undergoing segmental ureterectomy based on tumour location
by: Maksym Pikul, et al.
Published: (2025-06-01)

Characteristics and survival of primary urothelial carcinoma of the prostate: A multi-center retrospective study of 18 cases
by: Junjie Ji, et al.
Published: (2024-01-01)

The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens
by: Derek B. Allison, et al.
Published: (2022-04-01)

Remarkable response to fluorouracil, leucovorin, oxaliplatin, and irinotecan therapy in urothelial cancer of the renal pelvis: a case report
by: Takuya Tsujino, et al.
Published: (2017-04-01)

Poor Outcome due to the Plasmacytoid Variant of Urothelial Carcinoma
by: Kyotaro Fukuta, et al.
Published: (2022-03-01)

Editorial: Recent Advances in Diagnosis and Management of Urothelial Carcinoma
by: Ja Hyeon Ku, et al.
Published: (2021-03-01)

The role of focal adhesion kinase in bladder cancer: translation from in vitro to ex vivo human urothelial carcinomas
by: Markovic Gaja, et al.
Published: (2025-09-01)

A rare case of retroperitoneal recurrence as squamous cell carcinoma 10 years after nephroureterectomy
by: Koichiro Uehara, et al.
Published: (2025-01-01)

Case report: Two cases of leptomeningeal metastases in patients with metastatic urothelial carcinoma treated with enfortumab vedotin
by: Francine Fishbein, et al.
Published: (2024-11-01)

Incidences and oncological outcomes of urothelial carcinoma in kidney transplant recipients
by: Yu J, et al.
Published: (2018-12-01)

Primary Urothelial Carcinoma of the Anterior Urethra
by: McGeorge Stephen, et al.
Published: (2019-12-01)

[Cost Evaluation of First-Year Treatment for Locally Advanced or Metastatic Urothelial Carcinoma with Chemotherapy Plus Avelumab vs Chemotherapy Plus Best Supportive Care: A Cost of Care Model]
by: Daniela Paola Roggeri, et al.
Published: (2025-08-01)

Robot-assisted nephroureterectomy for upper urinary tract urothelial carcinoma without intraoperative reposition or redocking
by: Gu-Shun Lai, et al.
Published: (2016-09-01)

Metformin is associated with better survival rate of localized upper tract urothelial carcinoma patients with type 2 diabetes
by: Chung-Yu Lin, et al.
Published: (2023-01-01)

Urothelial carcinoma arising within bladder diverticulum—Report of a case and review of the literature
by: Hung-En Chen, et al.
Published: (2016-09-01)

RAPTOR gene polymorphism is independently correlated with urothelial cancer susceptibility compared with environmental toxin exposure
by: Hao Lun Luo, et al.
Published: (2017-12-01)

A unique case of protein-losing enteropathy in the setting of immune checkpoint inhibition case report
by: Ezra Bernstein, et al.
Published: (2023-09-01)

Synchronous primary tumors of the bladder: Successfully managed case
by: Farah Boutaggount, MD, et al.
Published: (2022-10-01)

Rectal constriction due to metastasis of urothelial carcinoma of the bladder: A case report
by: Kenji Tanabe, et al.
Published: (2021-11-01)

18F-FDG PET/CT in a Case of Urothelial Carcinoma in the Urachus Presenting as Colon Cancer
by: Jeannette D. Andersen, et al.
Published: (2021-12-01)

Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer
by: Jianheng Ye, et al.
Published: (2023-08-01)