Secretory Leukocyte Protease Inhibitor Is Present in Circulating and Tissue-Recruited Human Eosinophils and Regulates Their Migratory Function

Eosinophils and secretory leukocyte protease inhibitor (SLPI) are both associated with Th2 immune responses and allergic diseases, but whether the fact that they are both implicated in these conditions is pathophysiologically related remains unknown. Here we demonstrate that human eosinophils derive...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Oktawia Osiecka, Joanna Skrzeczynska-Moncznik, Agnieszka Morytko, Angelika Mazur, Pawel Majewski, Bernadetta Bilska, Monika Kapinska-Mrowiecka, Joanna Kosalka-Wegiel, Maciej Pastuszczak, Elzbieta Pyza, Joanna Cichy
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	secretory leukocyte protease inhibitor granulocyte eosinophil eosinophilic granulomatosis with polyangiitis (EGPA) atopic dermatitis (AD)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.737231/full