The eIg technology to generate Ig-like bispecific antibodies

Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve the light-chain problem for the generation of bispecific Ig-like antibodies using the second constant domain of IgE (EHD2) genetically modified...

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Bibliographic Details

Published in:	mAbs
Main Authors:	Lennart Kühl, Nadine Aschmoneit, Roland E. Kontermann, Oliver Seifert
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Subjects:	bispecific antibody hetEHD2 light chain problem MET EGFR HER3
Online Access:	https://www.tandfonline.com/doi/10.1080/19420862.2022.2063043