IMMUNOREACT 9 metachronous rectal cancers have high HLA-ABC expression on healthy epithelium but a lower infiltration of CD3+ T cells than primary lesions

Abstract Lynch syndrome is rarely associated with rectal cancer (RC) and thus, metachronous RC has been scarcely investigated. This study aimed to analyze the mucosal immune microenvironment in sporadic and metachronous RC. We analyzed the mucosal immune microenvironment in the 25 metachronous RCs p...

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Bibliographic Details
Published in:	Scientific Reports
Main Authors:	Beatrice Salmaso, Melania Scarpa, Valerio Pellegrini, Astghik Stepanyan, Roberta Salmaso, Andromachi Kotsafti, Federico Scognamiglio, Dario Gregori, Giorgio Rivella, Ottavia De Simoni, Giulia Becherucci, Silvia Negro, Chiara Vignotto, Gaya Spolverato, Cesare Ruffolo, Imerio Angriman, Francesca Bergamo, Valentina Chiminazzo, Isacco Maretto, Maurizio Zizzo, Francesco Marchegiani, Luca Facci, Stefano Brignola, Gianluca Businello, Laurino Licia, Vincenza Guzzardo, Luca Dal Santo, Ceccon Carlotta, Marco Massani, Anna Pozza, Ivana Cataldo, Tommaso Stecca, Angelo Paolo Dei Tos, Vittorina Zagonel, Pierluigi Pilati, Boris Franzato, Antonio Scapinello, Giulia Pozza, Mario Godina, Giovanni Pirozzolo, Alfonso Recordare, Isabella Mondi, Corrado Da Lio, Roberto Merenda, Giovanni Bordignon, Daunia Verdi, Luca Saadeh, Silvio Guerriero, Alessandra Piccioli, Giulia Noaro, Roberto Cola, Giuseppe Portale, Chiara Cipollari, Matteo Zuin, Salvatore Candioli, Laura Gavagna, Fabio Ricagna, Monica Ortenzi, Mario Guerrieri, Giovanni Tagliente, Monica Tomassi, Umberto Tedeschi, Andrea Porzionato, Marco Agostini, Riccardo Quoc Bao, Francesco Cavallin, Gaia Tussardi, Barbara Di Camillo, Romeo Bardini, Ignazio Castagliuolo, Salvatore Pucciarelli, Matteo Fassan, Marco Scarpa
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Online Access:	https://doi.org/10.1038/s41598-024-80299-0

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