Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches
Alkaloids are nitrogen-containing compounds naturally occurring in plants, microorganisms, and marine organisms. Potent biological activities have been reported to date, ranging from neuroprotective to antioxidant and anticancer effects. Alkaloids have recently gained attention as potential antifung...
| 出版年: | Pharmaceuticals |
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| 主要な著者: | , , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
MDPI AG
2025-04-01
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| 主題: | |
| オンライン･アクセス: | https://www.mdpi.com/1424-8247/18/4/589 |
| _version_ | 1849867146527506432 |
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| author | Denise Dozio Francesca Sacchi Andrea Pinto Sabrina Dallavalle Francesca Annunziata Salvatore Princiotto |
| author_facet | Denise Dozio Francesca Sacchi Andrea Pinto Sabrina Dallavalle Francesca Annunziata Salvatore Princiotto |
| author_sort | Denise Dozio |
| collection | DOAJ |
| container_title | Pharmaceuticals |
| description | Alkaloids are nitrogen-containing compounds naturally occurring in plants, microorganisms, and marine organisms. Potent biological activities have been reported to date, ranging from neuroprotective to antioxidant and anticancer effects. Alkaloids have recently gained attention as potential antifungal agents for crop protection due to their broad spectrum of activity, eco-friendly nature, and ability to overcome some of the issues associated with synthetic fungicides, such as resistance development and environmental contamination. Several efforts have been made to obtain natural and nature-derived alkaloids endowed with significant activity against numerous pathogenic fungal strains. In this review, we collect synthetic strategies developed over the past decade to produce alkaloid fungicides for crop protection. Special emphasis is given to recent advancements in obtaining pure natural compounds and more potent analogs endowed with tailored and optimized properties. |
| format | Article |
| id | doaj-art-cdf6e16916e54baeb1d292bc5fdf0ec2 |
| institution | Directory of Open Access Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-cdf6e16916e54baeb1d292bc5fdf0ec22025-08-20T01:16:28ZengMDPI AGPharmaceuticals1424-82472025-04-0118458910.3390/ph18040589Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic ApproachesDenise Dozio0Francesca Sacchi1Andrea Pinto2Sabrina Dallavalle3Francesca Annunziata4Salvatore Princiotto5Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, ItalyAlkaloids are nitrogen-containing compounds naturally occurring in plants, microorganisms, and marine organisms. Potent biological activities have been reported to date, ranging from neuroprotective to antioxidant and anticancer effects. Alkaloids have recently gained attention as potential antifungal agents for crop protection due to their broad spectrum of activity, eco-friendly nature, and ability to overcome some of the issues associated with synthetic fungicides, such as resistance development and environmental contamination. Several efforts have been made to obtain natural and nature-derived alkaloids endowed with significant activity against numerous pathogenic fungal strains. In this review, we collect synthetic strategies developed over the past decade to produce alkaloid fungicides for crop protection. Special emphasis is given to recent advancements in obtaining pure natural compounds and more potent analogs endowed with tailored and optimized properties.https://www.mdpi.com/1424-8247/18/4/589alkaloidscrop protectionfungicidetotal synthesisphytopathogenic fungi |
| spellingShingle | Denise Dozio Francesca Sacchi Andrea Pinto Sabrina Dallavalle Francesca Annunziata Salvatore Princiotto Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches alkaloids crop protection fungicide total synthesis phytopathogenic fungi |
| title | Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches |
| title_full | Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches |
| title_fullStr | Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches |
| title_full_unstemmed | Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches |
| title_short | Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches |
| title_sort | natural antifungal alkaloids for crop protection an overview of the latest synthetic approaches |
| topic | alkaloids crop protection fungicide total synthesis phytopathogenic fungi |
| url | https://www.mdpi.com/1424-8247/18/4/589 |
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