Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury

Abstract After spinal cord injury (SCI), neutrophil elastase (NE) released at injury site disrupts vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are vascular growth factors that play an important role in vascular stabilization. We hypothesized that neutrophil elastase is o...

Full description

Bibliographic Details
Published in:	Acta Neuropathologica Communications
Main Authors:	Hemant Kumar, Hyemin Choi, Min-Jae Jo, Hari Prasad Joshi, Manjunatha Muttigi, Dario Bonanomi, Sung Bum Kim, Eunmi Ban, Aeri Kim, Soo-Hong Lee, Kyoung-Tae Kim, Seil Sohn, Xiang Zeng, Inbo Han
Format:	Article
Language:	English
Published:	BMC 2018-08-01
Subjects:	Neutrophil elastase Spinal cord injury Glial scar Angiopoietins Functional recovery Neuropathic pain
Online Access:	http://link.springer.com/article/10.1186/s40478-018-0576-3

Similar Items

Neutrophil elastase in bronchiectasis
by: Andrea Gramegna, et al.
Published: (2017-12-01)

Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer
by: Hui Yang, et al.
Published: (2021-09-01)

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
by: Kelli L. Sylvers-Davie, et al.
Published: (2021-01-01)

Arsenic trioxide inhibits angiogenesis of hepatocellular carcinoma after insufficient radiofrequency ablation via blocking paracrine angiopoietin-1 and angiopoietin-2
by: Shuying Dong, et al.
Published: (2022-12-01)

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically
by: Joanna Kalupa, et al.
Published: (2011-06-01)

Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice
by: Daxin Chen, et al.
Published: (2018-07-01)

Serum Angiopoietin-1/Angiopoietin-2 at 16-18 Weeks of Gestation to Predict Preeclampsia
by: Vorapong Phupong, et al.
Published: (2021-07-01)

Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients
by: Luu Thi Thanh Duyen, et al.
Published: (2022-12-01)

Serum angiopoietin-2/angiopoietin-1 ratio is associated with cardiovascular and all-cause mortality in peritoneal dialysis patients: a prospective cohort study
by: Han Li, et al.
Published: (2024-12-01)

The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma
by: Bart Vanderborght, et al.
Published: (2020-10-01)

Impact of Angiopoietin-2 on Kidney Diseases
by: Mei Li, et al.
Published: (2023-03-01)

Value of circulating neutrophil elastase for detecting recurrence of differentiated thyroid cancer
by: Hyunjae Lee, et al.
Published: (2023-11-01)

In vitro study on the inhibitory effects of Korean brown, green, and red seaweed extracts on collagenase, elastase, and hyaluronidase
by: Hyo-Bin Kim, et al.
Published: (2024-11-01)

BACILLUS THURINGIENSIS ELASTASES WITH INSECTICIDE ACTIVITY
by: E. V. Matseliukh, et al.
Published: (2015-10-01)

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves
by: Panagiota Tsiatsiou, et al.
Published: (2024-04-01)

Role of Angiopoietins in Development of Cancer and Neoplasia Associated with Viral Infection
by: Xiaolan Yu, et al.
Published: (2020-02-01)

Strong inhibition of xanthine oxidase and elastase of Baccharis trimera (Less.) DC stem extract and analysis of biologically active constituents
by: Seung-Yub Song, et al.
Published: (2023-05-01)

Angiopoietins as biomarkers of schistosomiasis severity: a cross-sectional study
by: Rachael Lima Sobreira Coimbra, et al.

Relationship of angiopoietin-2 level with the prognosis of the COVID-19 disease
by: Olgun Keskin, et al.
Published: (2023-10-01)

Increased Neutrophil Elastase in Affected Lobes of Bronchiectasis and Correlation of Its Levels between Sputum and Bronchial Lavage Fluid
by: Lam Nguyen-Ho, et al.
Published: (2025-04-01)

Effects of Galgeungyulpitang on Cellular Production of Melanin and Elastase
by: Na Young Jo, et al.
Published: (2019-02-01)

Development of different degrees of elastase-induced emphysema in mice: a randomized controlled experimental studyenfisema pulmonar, mecânica pulmonar, elastase pancreática.
by: Cristiana Palma Kuhl, et al.
Published: (2014-10-01)

Development of different degrees of elastase-induced emphysema in mice: a randomized controlled experimental studyenfisema pulmonar, mecânica pulmonar, elastase pancreática.
by: Cristiana Palma Kuhl, et al.
Published: (2014-10-01)

Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity
by: Fátima A. R. Mota, et al.
Published: (2021-01-01)

Standardised Sonneratia apetala Buch.-Ham. fruit extract inhibits human neutrophil elastase and attenuates elastase-induced lung injury in mice
by: Sayantan Sengupta, et al.
Published: (2022-12-01)

Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation—A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients
by: Michael Hultström, et al.
Published: (2022-06-01)

miR-1233-3p Inhibits Angiopoietin-1-Induced Endothelial Cell Survival, Migration, and Differentiation
by: Veronica Sanchez, et al.
Published: (2025-01-01)

Granular Insights: Neutrophil Predominance and Elastase Release in Severe Asthma Exacerbations in a Pediatric Cohort
by: Kirstin Henley, et al.
Published: (2024-03-01)

Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria
by: Srinivas H Gowda, et al.
Published: (2020-01-01)

A neutrophil elastase inhibitor, sivelestat, attenuates sepsis-induced acute kidney injury by inhibiting oxidative stress
by: Wei Zhu, et al.
Published: (2024-04-01)

Iridal-Type Triterpenoids Displaying Human Neutrophil Elastase Inhibition and Anti-Inflammatory Effects from <i>Belamcanda chinensis</i>
by: Jeong Ho Kim, et al.
Published: (2021-10-01)

Understanding the Role of the Glial Scar through the Depletion of Glial Cells after Spinal Cord Injury
by: Lucila Perez-Gianmarco, et al.
Published: (2023-07-01)

Screening of elastase-producing strains and primariry atudies on fermentation conditions
by: CHEN Qi-he, et al.
Published: (2003-01-01)

Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase
by: Karolina Torzyk-Jurowska, et al.
Published: (2024-03-01)

The ratio of serum Angiopoietin-1 to Angiopoietin-2 in patients with cervical cancer is a valuable diagnostic and prognostic biomarker
by: Ping Yang, et al.
Published: (2017-05-01)

Reduced Angiopoietin Factor 2 Levels Are Correlated with Better Cardiac Function and Prognosis in Valvular Heart Disease
by: Jian Hou, et al.
Published: (2022-06-01)

Trypsin, chymotrypsin and elastase in health and disease
by: Oladoyin Grace Famutimi, et al.
Published: (2024-09-01)

Corrigendum: Standardised Sonneratia apetala Buch.-Ham. fruit extract inhibits human neutrophil elastase and attenuates elastase-induced lung injury in mice
by: Sayantan Sengupta, et al.
Published: (2023-04-01)

Regulation of the angiopoietin-like protein 3 gene by LXR
by: Rebecca Kaplan, et al.
Published: (2003-01-01)

Essential Oil of <i>Citrus aurantium</i> L. Leaves: Composition, Antioxidant Activity, Elastase and Collagenase Inhibition
by: Chahinez Oulebsir, et al.
Published: (2022-06-01)