Methods for predicting vaccine immunogenicity and reactogenicity

Subjects receiving the same vaccine often show different levels of immune responses and some may even present adverse side effects to the vaccine. Systems vaccinology can combine omics data and machine learning techniques to obtain highly predictive signatures of vaccine immunogenicity and reactogen...

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Bibliographic Details
Published in:Human Vaccines & Immunotherapeutics
Main Authors: Patrícia Gonzalez-Dias, Eva K. Lee, Sara Sorgi, Diógenes S. de Lima, Alysson H. Urbanski, Eduardo Lv Silveira, Helder I. Nakaya
Format: Article
Language:English
Published: Taylor & Francis Group 2020-02-01
Subjects:
systems vaccinology
machine learning
vaccine immunogenicity
vaccine reactogenicity
artificial intelligence
Online Access:http://dx.doi.org/10.1080/21645515.2019.1697110
Description
Summary:Subjects receiving the same vaccine often show different levels of immune responses and some may even present adverse side effects to the vaccine. Systems vaccinology can combine omics data and machine learning techniques to obtain highly predictive signatures of vaccine immunogenicity and reactogenicity. Currently, several machine learning methods are already available to researchers with no background in bioinformatics. Here we described the four main steps to discover markers of vaccine immunogenicity and reactogenicity: (1) Preparing the data; (2) Selecting the vaccinees and relevant genes; (3) Choosing the algorithm; (4) Blind testing your model. With the increasing number of Systems Vaccinology datasets being generated, we expect that the accuracy and robustness of signatures of vaccine reactogenicity and immunogenicity will significantly improve.
ISSN:2164-5515
2164-554X

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