Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance
Abstract Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associ...
| 出版年: | Biomarker Research |
|---|---|
| 主要な著者: | , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
BMC
2023-02-01
|
| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1186/s40364-023-00467-8 |
| _version_ | 1852686034442125312 |
|---|---|
| author | Junhui Hou Gong Zhang Xia Wang Yuan Wang Kefeng Wang |
| author_facet | Junhui Hou Gong Zhang Xia Wang Yuan Wang Kefeng Wang |
| author_sort | Junhui Hou |
| collection | DOAJ |
| container_title | Biomarker Research |
| description | Abstract Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment. |
| format | Article |
| id | doaj-art-ce49b8ec414e44b6ba30e976c8d8dc97 |
| institution | Directory of Open Access Journals |
| issn | 2050-7771 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| spelling | doaj-art-ce49b8ec414e44b6ba30e976c8d8dc972025-08-19T21:26:41ZengBMCBiomarker Research2050-77712023-02-0111111110.1186/s40364-023-00467-8Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistanceJunhui Hou0Gong Zhang1Xia Wang2Yuan Wang3Kefeng Wang4Department of Urology, Shengjing Hospital of China Medical UniversityDepartment of Urology, Shengjing Hospital of China Medical UniversityDepartment of Urology, Shengjing Hospital of China Medical UniversityDepartment of General Surgery, Shengjing Hospital of China Medical UniversityDepartment of Urology, Shengjing Hospital of China Medical UniversityAbstract Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.https://doi.org/10.1186/s40364-023-00467-8Long non-coding RNAMALAT1Chemotherapy resistanceCancerTreatment |
| spellingShingle | Junhui Hou Gong Zhang Xia Wang Yuan Wang Kefeng Wang Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance Long non-coding RNA MALAT1 Chemotherapy resistance Cancer Treatment |
| title | Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance |
| title_full | Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance |
| title_fullStr | Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance |
| title_full_unstemmed | Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance |
| title_short | Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance |
| title_sort | functions and mechanisms of lncrna malat1 in cancer chemotherapy resistance |
| topic | Long non-coding RNA MALAT1 Chemotherapy resistance Cancer Treatment |
| url | https://doi.org/10.1186/s40364-023-00467-8 |
| work_keys_str_mv | AT junhuihou functionsandmechanismsoflncrnamalat1incancerchemotherapyresistance AT gongzhang functionsandmechanismsoflncrnamalat1incancerchemotherapyresistance AT xiawang functionsandmechanismsoflncrnamalat1incancerchemotherapyresistance AT yuanwang functionsandmechanismsoflncrnamalat1incancerchemotherapyresistance AT kefengwang functionsandmechanismsoflncrnamalat1incancerchemotherapyresistance |