Tumor microenvironment-responsive metal nanotherapeutics for breast cancer chemo-/immunotherapy

Abstract Many metal complexes not only had excellent cytotoxic antitumor effects but also could function as a positive immunomodulatory to improve antitumor effects by modifying the local tumor microenvironment. Herein, a dual-target nanotherapeutics (MP3/ACPP/AE105@NPs) with uPAR targeting and tumo...

Full description

Bibliographic Details
Published in:	NPG Asia Materials
Main Authors:	Jinggong Liu, Wenying Li, Yongpeng Lin, Yongjun Peng, Meixiao Zhan, Haoqiang Lai, Yanzhou Chang, Yongjin Li, Ka-hing Wong, Bolai Chen, Tianfeng Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-04-01
Online Access:	https://doi.org/10.1038/s41427-023-00473-0

Similar Items

Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment
by: Siyuan Rao, et al.
Published: (2022-06-01)

Metal-Organic Framework-Based Nanotherapeutics With Tumor Hypoxia-Relieving Ability for Synergistic Sonodynamic/Chemo-therapy
by: Lichang Zhong, et al.
Published: (2022-03-01)

Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools
by: Li R, et al.
Published: (2024-12-01)

Self-disassembling nanoparticles as oral nanotherapeutics targeting intestinal microenvironment
by: Jinwon Park, et al.
Published: (2025-04-01)

Losartan-based nanocomposite hydrogel overcomes chemo-immunotherapy resistance by remodeling tumor mechanical microenvironment
by: Xiaodong Hou, et al.
Published: (2024-10-01)

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
by: Yun Chang, et al.
Published: (2023-04-01)

Programming Injectable DNA Hydrogels Yields Tumor Microenvironment‐Activatable and Immune‐Instructive Depots for Augmented Chemo‐Immunotherapy
by: Yu Fan, et al.
Published: (2023-10-01)

Nanotherapeutics Plus Immunotherapy in Oncology: Who Brings What to the Table?
by: Elise Timon-David, et al.
Published: (2022-10-01)

Correction: Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review
by: Xingtao Zhao, et al.
Published: (2023-05-01)

Triple‐Combination Immunogenic Nanovesicles Reshape the Tumor Microenvironment to Potentiate Chemo‐Immunotherapy in Preclinical Cancer Models
by: Xiaowei Shi, et al.
Published: (2023-05-01)

Novel Nanotherapeutics for Cancer Immunotherapy by PD-L1-Aptamer-Functionalized and Fexofenadine-Loaded Albumin Nanoparticles
by: Xialian Lai, et al.
Published: (2023-03-01)

Novel nanotherapeutics for cancer immunotherapy by albumin nanoparticles functionalized with PD-1 and PD-L1 aptamers
by: Qiping Jiang, et al.
Published: (2024-01-01)

Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer
by: Wei Huang, et al.
Published: (2023-09-01)

Supramolecular nanotherapeutics based on cucurbiturils
by: Maiyier Muheyati, et al.
Published: (2024-12-01)

Tumor microenvironment-responsive micelles assembled from a prodrug of mitoxantrone and 1-methyl tryptophan for enhanced chemo-immunotherapy
by: Ru Wang, et al.
Published: (2023-12-01)

Highly active selenium nanotherapeutics combined with metformin to achieve synergistic sensitizing effect on NK cells for osteosarcoma therapy
by: Du Yanxin, et al.
Published: (2022-06-01)

Dynamic modulation of claudin18.2 expression and remodeling of the tumor microenvironment in gastric cancer during chemo-immunotherapy
by: Takeshi Kuwata, et al.
Published: (2025-09-01)

Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
by: Zhiheng Zeng, et al.
Published: (2022-12-01)

Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease
by: Chang Liu, et al.
Published: (2024-07-01)

Nanomedicines targeting activation of STING to reshape tumor immune microenvironment and enhance immunotherapeutic efficacy
by: Shanshan Chen, et al.
Published: (2023-01-01)

Polyphosphazene-Based Nanotherapeutics
by: Sara Gutierrez-Gutierrez, et al.
Published: (2025-08-01)

Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy
by: Zaigang Zhou, et al.
Published: (2024-09-01)

Epithelial to Mesenchymal Transition Relevant Subtypes with Distinct Prognosis and Responses to Chemo- or Immunotherapies in Osteosarcoma
by: Yang Zhou, et al.
Published: (2022-01-01)

Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy
by: Ying Zhang, et al.
Published: (2022-08-01)

Intelligent nanotherapeutic strategies for the delivery of CRISPR system
by: Chao Chen, et al.
Published: (2023-06-01)

Smart Nanotherapeutics and Lung Cancer
by: Mohammad Doroudian, et al.
Published: (2021-11-01)

Consideration of Pneumonectomy in the Era of Chemo-Immunotherapy in Resectable NSCLC
by: Ibrahim Azar, et al.
Published: (2025-01-01)

Dramatic response of metaplastic breast cancer to chemo-immunotherapy
by: Sylvia Adams
Published: (2017-03-01)

Targeting Nanotherapeutics for Highly Efficient Diagnosis and Treatment of Systemic Lupus Erythematosus through Regulation of Immune Response
by: Ting Liu, et al.
Published: (2025-05-01)

Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury
by: Luoqi Mai, et al.
Published: (2025-06-01)

Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy
by: Gloriana Ndembe, et al.
Published: (2024-01-01)

RNA nanotherapeutics with fibrosis overexpression and retention for MASH treatment
by: Xinzhu Shan, et al.
Published: (2024-08-01)

Case Report: Therapeutic Response to Chemo-Immunotherapy in an Advanced Large Cell Lung Carcinoma Patient With Low Values of Multiple Predictive Biomarkers
by: Guihua Wang, et al.
Published: (2021-01-01)

Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy
by: Xiaoju Guo, et al.
Published: (2024-04-01)

Tumor microenvironment-responsive BSA nanocarriers for combined chemo/chemodynamic cancer therapy
by: Ruiyi Zhang, et al.
Published: (2022-05-01)

CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer
by: Hai Cai, et al.
Published: (2025-07-01)

Editorial: Nanodrug delivery strategies for enhanced cancer chemo-immunotherapy
by: Yufen Xiao, et al.
Published: (2025-07-01)

Optimal dosage protocols for mathematical models of synergy of chemo- and immunotherapy
by: Urszula Ledzewicz, et al.
Published: (2024-01-01)

Size-transformable nanotherapeutics for cancer therapy
by: Teng Ma, et al.
Published: (2025-02-01)

Biochemical hallmarks-targeting antineoplastic nanotherapeutics
by: Jing Han, et al.
Published: (2024-06-01)