Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications
This study explores the potential of ginseng-derived peptides (GPs) as multifunctional bioactive agents for skincare. Unlike previous research into ginseng saponins and polysaccharides, we identified that ginseng extracts containing water-soluble small molecules and polypeptides exhibit potent antio...
| 出版年: | Cosmetics |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
MDPI AG
2025-04-01
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| 主題: | |
| オンライン･アクセス: | https://www.mdpi.com/2079-9284/12/2/85 |
| _version_ | 1849575479559847936 |
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| author | Ze Xia Wei Liu Fanmo Zeng Sining Kang Junxiang Li Wenfei Xu Pingxiang Tang Xinyi Zheng Dandan Li Xuebin Yang Qing Sheng Xuhui Li |
| author_facet | Ze Xia Wei Liu Fanmo Zeng Sining Kang Junxiang Li Wenfei Xu Pingxiang Tang Xinyi Zheng Dandan Li Xuebin Yang Qing Sheng Xuhui Li |
| author_sort | Ze Xia |
| collection | DOAJ |
| container_title | Cosmetics |
| description | This study explores the potential of ginseng-derived peptides (GPs) as multifunctional bioactive agents for skincare. Unlike previous research into ginseng saponins and polysaccharides, we identified that ginseng extracts containing water-soluble small molecules and polypeptides exhibit potent antioxidant, anti-inflammatory, and anti-aging properties. In vitro assays revealed that ginseng peptide extract (GPE) reduced reactive oxygen species (ROS) and inflammatory cytokines (IL-6, TNF-α, IL-1β) in RAW264.7 macrophages while enhancing collagen synthesis in human skin fibroblasts (HSFs). Validation using 3D epidermal and dermal models further confirmed GPE’s ability to mitigate UV-induced damage, restore skin barrier proteins (filaggrin, loricrin), and increase collagen content. In addition, we screened 19 candidate peptides from ginseng extract using machine learning and prioritized their interaction with skin aging and inflammation-related targets. Three peptides (QEGIYPNNDLYRPK, VDCPTDDATDDYRLK, and ADEVVHHPLDKSSEVE) demonstrated significant collagen-promoting, antioxidant, and anti-inflammatory effects in cellular models. These findings highlight the efficacy of computational approaches in identifying natural bioactive ingredients, positioning ginseng peptides as promising candidates for innovative cosmeceutical formulations targeting inflammaging and skin rejuvenation. |
| format | Article |
| id | doaj-art-cfdde93033db479ab610a255baf2c0a9 |
| institution | Directory of Open Access Journals |
| issn | 2079-9284 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-cfdde93033db479ab610a255baf2c0a92025-08-20T02:28:20ZengMDPI AGCosmetics2079-92842025-04-011228510.3390/cosmetics12020085Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare ApplicationsZe Xia0Wei Liu1Fanmo Zeng2Sining Kang3Junxiang Li4Wenfei Xu5Pingxiang Tang6Xinyi Zheng7Dandan Li8Xuebin Yang9Qing Sheng10Xuhui Li11College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaBeijing Yiqing Daily Chemical Co., Ltd., Tongzhou 101100, ChinaAGECODE R&D Center, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314000, ChinaAGECODE R&D Center, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314000, ChinaAGECODE R&D Center, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314000, ChinaZhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314006, ChinaZhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314006, ChinaZhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314006, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaZhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, Jiaxing 314006, ChinaThis study explores the potential of ginseng-derived peptides (GPs) as multifunctional bioactive agents for skincare. Unlike previous research into ginseng saponins and polysaccharides, we identified that ginseng extracts containing water-soluble small molecules and polypeptides exhibit potent antioxidant, anti-inflammatory, and anti-aging properties. In vitro assays revealed that ginseng peptide extract (GPE) reduced reactive oxygen species (ROS) and inflammatory cytokines (IL-6, TNF-α, IL-1β) in RAW264.7 macrophages while enhancing collagen synthesis in human skin fibroblasts (HSFs). Validation using 3D epidermal and dermal models further confirmed GPE’s ability to mitigate UV-induced damage, restore skin barrier proteins (filaggrin, loricrin), and increase collagen content. In addition, we screened 19 candidate peptides from ginseng extract using machine learning and prioritized their interaction with skin aging and inflammation-related targets. Three peptides (QEGIYPNNDLYRPK, VDCPTDDATDDYRLK, and ADEVVHHPLDKSSEVE) demonstrated significant collagen-promoting, antioxidant, and anti-inflammatory effects in cellular models. These findings highlight the efficacy of computational approaches in identifying natural bioactive ingredients, positioning ginseng peptides as promising candidates for innovative cosmeceutical formulations targeting inflammaging and skin rejuvenation.https://www.mdpi.com/2079-9284/12/2/85ginseng peptideinflammagingnetwork pharmacologymachine learningdermatology |
| spellingShingle | Ze Xia Wei Liu Fanmo Zeng Sining Kang Junxiang Li Wenfei Xu Pingxiang Tang Xinyi Zheng Dandan Li Xuebin Yang Qing Sheng Xuhui Li Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications ginseng peptide inflammaging network pharmacology machine learning dermatology |
| title | Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications |
| title_full | Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications |
| title_fullStr | Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications |
| title_full_unstemmed | Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications |
| title_short | Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications |
| title_sort | systematic evaluation and identification of anti inflammatory and anti aging ginseng peptides for skincare applications |
| topic | ginseng peptide inflammaging network pharmacology machine learning dermatology |
| url | https://www.mdpi.com/2079-9284/12/2/85 |
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