Zombies Never Die: The Double Life Bub1 Lives in Mitosis

When eukaryotic cells enter mitosis, dispersed chromosomes move to the cell center along microtubules to form a metaphase plate which facilitates the accurate chromosome segregation. Meanwhile, kinetochores not stably attached by microtubules activate the spindle assembly checkpoint and generate a w...

Full description

Bibliographic Details
Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Yuqing Zhang, Chunlin Song, Lei Wang, Hongfei Jiang, Yujing Zhai, Ying Wang, Jing Fang, Gang Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Subjects:	mitosis spindle assembly checkpoint kinetochore Bub1 chromosome alignment
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.870745/full

Similar Items

BUB3, beyond the Simple Role of Partner
by: Patrícia M. A. Silva, et al.
Published: (2022-05-01)

Cenp-meta is required for sustained spindle checkpoint
by: Thomas Rubin, et al.
Published: (2014-05-01)

Checkpoint proteins come under scrutiny
by: Maria Mora-Santos, et al.
Published: (2013-10-01)

Kinetoplastid kinetochore proteins KKT14–KKT15 are divergent Bub1/BubR1–Bub3 proteins
by: Daniel Ballmer, et al.
Published: (2024-06-01)

The equatorial position of the metaphase plate ensures symmetric cell divisions
by: Chia Huei Tan, et al.
Published: (2015-07-01)

CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis
by: Wonkyung Oh, et al.
Published: (2022-09-01)

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription
by: Marco Novais-Cruz, et al.
Published: (2018-08-01)

Recent advances in plant kinetochore research
by: Elena Kozgunova, et al.
Published: (2025-01-01)

Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint
by: Ikram Mossaid, et al.
Published: (2015-11-01)

BUB1B and gynecological malignant tumors
by: HOU Yiying, WEI Fang
Published: (2024-12-01)

Fission yeast Wee1 is required for stable kinetochore-microtubule attachment
by: Masahiro Takado, et al.
Published: (2024-01-01)

Kre28–Spc105 interaction is essential for Spc105 loading at the kinetochore
by: Babhrubahan Roy, et al.
Published: (2022-01-01)

Exploring Plant Meiosis: Insights from the Kinetochore Perspective
by: Kang-Di Zhou, et al.
Published: (2023-09-01)

Insights into mitotic checkpoint by integrating CRISPR and RNAi
by: Gang Zhang
Published: (2019-07-01)

Mechanisms of Chromosome Congression during Mitosis
by: Helder Maiato, et al.
Published: (2017-02-01)

Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
by: KC Farrell, et al.
Published: (2024-08-01)

Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation
by: Duccio Conti, et al.
Published: (2019-12-01)

The roles of kinetochore of micronucleus in mitosis of HeLa cells: a live cell imaging study
by: Erkang Jiang, et al.
Published: (2019-08-01)

The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint
by: Babhrubahan Roy, et al.
Published: (2020-06-01)

The importance of microtubule-dependent tension in accurate chromosome segregation
by: Angela R. Bunning, et al.
Published: (2023-01-01)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore
by: Giulia Vallardi, et al.
Published: (2019-03-01)

Generation and diversification of recombinant monoclonal antibodies
by: Keith F DeLuca, et al.
Published: (2021-12-01)

Effects of malleable kinetochore morphology on measurements of intrakinetochore tension
by: Fioranna Renda, et al.
Published: (2020-07-01)

Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast
by: Yueyue Jiang, et al.
Published: (2025-08-01)

Some assembly required: Redefining the mitotic checkpoint
by: John C. Meadows, et al.
Published: (2017-11-01)

The establishment of mitotic errors-driven senescence depends on autophagy
by: Andreas Goutas, et al.
Published: (2023-06-01)

Overexpression of BubR1 Mitotic Checkpoint Protein Predicts Short Survival and Influences the Progression of Cholangiocarcinoma
by: Nongnapas Pokaew, et al.
Published: (2024-07-01)

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores
by: Zhen Dou, et al.
Published: (2019-03-01)

Mechanical coupling coordinates microtubule growth
by: Bonnibelle K Leeds, et al.
Published: (2023-12-01)

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization
by: Jiao Wang, et al.
Published: (2016-06-01)

Combinatorial Use of Chitosan Nanoparticles, Reversine, and Ionising Radiation on Breast Cancer Cells Associated with Mitosis Deregulation
by: Sofia Piña Olmos, et al.
Published: (2019-05-01)

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling
by: Zhejian Ji, et al.
Published: (2017-01-01)

Aurora kinases: Generators of spatial control during mitosis
by: Aamir Ali, et al.
Published: (2023-03-01)

Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis
by: Renju Pun, et al.
Published: (2025-01-01)

Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer
by: Huicong Zhang, et al.
Published: (2024-07-01)

CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC
by: Qi Li, et al.
Published: (2024-09-01)

In situ visualization of a simple bipartite kinetochore with a single microtubule attachment in Giardia intestinalis (Metamonada)
by: Pavla Tůmová, et al.
Published: (2022-04-01)

A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint
by: Ajit P. Joglekar
Published: (2016-11-01)

Spatial Rule-Based Modeling: A Method and Its Application to the Human Mitotic Kinetochore
by: Jan Huwald, et al.
Published: (2013-07-01)

The pseudo GTPase CENP-M drives human kinetochore assembly
by: Federica Basilico, et al.
Published: (2014-07-01)