In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi

Geldanamycin (GA) is a benzoquinone-containing ansamycin that inhibits heat shock protein 90. GA derivatives are being evaluated as anti-neoplastic agents, but their utility against parasites whose heat shock proteins (Hsps) have homology with human Hsp90 is unknown. The activities of four syntheti...

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Bibliographic Details
Published in:	Journal of Parasitology Research
Main Authors:	David Wenkert, Bernadette Ramirez, Yuehai Shen, Michael A. Kron
Format:	Article
Language:	English
Published:	Wiley 2010-01-01
Online Access:	http://dx.doi.org/10.1155/2010/716498

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