Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish

Summary: LDLR, as the uptake receptor of low-density lipoprotein, plays a crucial role in lipid metabolism. However, the detailed mechanism by which LDLR affects hepatic triglyceride (TG) accumulation has rarely been reported. Here, we found that knockdown of LDLR effectively mitigated PA-induced TG...

Full description

Bibliographic Details
Published in:	iScience
Main Authors:	Xiufei Cao, Wei Fang, Xueshan Li, Xiuneng Wang, Kangsen Mai, Qinghui Ai
Format:	Article
Language:	English
Published:	Elsevier 2022-07-01
Subjects:	Biological sciences Zoology Cell biology Functional aspects of cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004222009427

Similar Items

Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
by: Jie Sun, et al.
Published: (2023-11-01)

Positional information modulates transient regeneration-activated cell states during vertebrate appendage regeneration
by: Augusto Ortega Granillo, et al.
Published: (2024-09-01)

Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways
by: Tianxiang Wang, et al.
Published: (2024-05-01)

PolyQ length-based molecular encoding of vocalization frequency in FOXP2
by: Serena Vaglietti, et al.
Published: (2023-10-01)

UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice
by: Xiaochen Yu, et al.
Published: (2025-08-01)

Homo-oxidized HSPB1 protects H9c2 cells against oxidative stress via activation of KEAP1/NRF2 signaling pathway
by: Nian Wang, et al.
Published: (2023-08-01)

Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes
by: Mark Germanos, et al.
Published: (2025-02-01)

Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo
by: Juan A. Garcia-Sanchez, et al.
Published: (2025-02-01)

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading
by: Pei-Li Tseng, et al.
Published: (2025-04-01)

Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
by: Xin Xu, et al.
Published: (2023-10-01)

Nonlinear phenomena make animal calls alarming for human listeners
by: Anna Terrade, et al.
Published: (2025-06-01)

Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish
by: Fengyan Zhang, et al.
Published: (2024-03-01)

MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species
by: Chaogang Wang, et al.
Published: (2024-07-01)

Prosociality in a despotic society
by: Debottam Bhattacharjee, et al.
Published: (2023-05-01)

Offspring nursing extends mother’s longevity in a long-term maternal cared spider
by: Chu Jiang, et al.
Published: (2024-06-01)

Changes in local interaction rules during ontogeny underlie the evolution of collective behavior
by: Alexandra Paz, et al.
Published: (2023-09-01)

The genome of African manatee Trichechus senegalensis reveals secondary adaptation to the aquatic environment
by: Xin Huang, et al.
Published: (2024-07-01)

Early-life intraguild predation risk produces adaptive personalities in predatory mites
by: Peter Schausberger, et al.
Published: (2024-03-01)

Tradeoffs between mating effort and parenting effort in a polygynandrous mammal
by: Caitlin R. Hawley, et al.
Published: (2023-07-01)

Chimpanzees show the capacity to communicate about concomitant daily life events
by: Tatiana Bortolato, et al.
Published: (2023-11-01)

Emergence of novel genomic regulatory regions associated with light-organ development in the bobtail squid
by: Lisa Rouressol, et al.
Published: (2023-07-01)

Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature
by: Yong-Xu Sun, et al.
Published: (2023-03-01)

Sound categorization by crocodilians
by: Julie Thévenet, et al.
Published: (2023-04-01)

Dynamic Malignant Wave of Ribosome-Insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit
by: Ki Hyung Kim, et al.
Published: (2020-05-01)

Somatic Miwi2 modulates mitochondrial function in airway multiciliated cells and exacerbates influenza pathogenesis
by: Jhonatan Henao Vasquez, et al.
Published: (2025-04-01)

Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation
by: Delia I. Fernández, et al.
Published: (2022-01-01)

Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity
by: Gabriel Ruiz-Romero, et al.
Published: (2024-11-01)

Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca2+-PIK3CA pathway
by: Lingyi Song, et al.
Published: (2025-01-01)

Targeting ABCG1 and SREBP-2 mediated cholesterol homeostasis ameliorates Zika virus-induced ocular pathology
by: Sneha Singh, et al.
Published: (2024-03-01)

Regulation of pericentromeric DNA loop size via Scc2-cohesin interaction
by: Sao Anh Nguyen, et al.
Published: (2025-05-01)

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells
by: Samuel L. Junod, et al.
Published: (2023-08-01)

Characterization of C2H2 superfamily expansions in cephalopods and their contribution to nervous system evolution
by: Christina Holzinger, et al.
Published: (2025-10-01)

Myosin cluster dynamics determines epithelial wound ring constriction
by: Alka Bhat, et al.
Published: (2025-08-01)

A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans
by: Jimmy H. Mo, et al.
Published: (2025-02-01)

P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis
by: Sydnie K. Tran, et al.
Published: (2025-02-01)

The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner
by: Tomoko Okuyama, et al.
Published: (2025-02-01)

Cryo-ET of actin cytoskeleton and membrane structure in lamellipodia formation using optogenetics
by: Hironori Inaba, et al.
Published: (2025-06-01)

Differential N-terminal processing of beta and gamma actin
by: Li Chen, et al.
Published: (2022-10-01)

Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin
by: Matthias Przyklenk, et al.
Published: (2022-10-01)

Tricalbins Are Required for Non-vesicular Ceramide Transport at ER-Golgi Contacts and Modulate Lipid Droplet Biogenesis
by: Atsuko Ikeda, et al.
Published: (2020-10-01)