A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance

The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity against bacteria. However, Amberg Johnson et a...

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Bibliographic Details
Published in:	eLife
Main Authors:	Christopher D Goodman, Taher Uddin, Natalie J Spillman, Geoffrey I McFadden
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-07-01
Subjects:	actinonin FTSH1 resistance apicoplast
Online Access:	https://elifesciences.org/articles/58629

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