The potential impact of hereditary hemochromatosis on the heart considering the disease stage and patient age—the role of echocardiography

BackgroundHereditary hemochromatosis (HH) is a genetic disease that leads to increased iron accumulation in several organs. Cardiomyocytes are highly susceptible to this damage owing to their high iron uptake, and cardiovascular complications account for 1/3 of the deaths in the natural course of HH...

Full description

Bibliographic Details
Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Michał Świątczak, Katarzyna Rozwadowska, Katarzyna Sikorska, Krzysztof Młodziński, Agata Świątczak, Grzegorz Raczak, Ludmiła Daniłowicz-Szymanowicz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	hereditary hemochromatosis speckle-tracking echocardiography echocardiography cardiovascular ageing iron overload (IO)
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1202961/full

Similar Items

Pathogenesis, Diagnosis, and Clinical Implications of Hereditary Hemochromatosis—The Cardiological Point of View
by: Ludmiła Daniłowicz-Szymanowicz, et al.
Published: (2021-07-01)

Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis
by: CAROLINE A ENNS
Published: (2006-01-01)

Genotypic and phenotypic spectra of hemojuvelin mutations in primary hemochromatosis patients: a systematic review
by: Xiaomu Kong, et al.
Published: (2019-07-01)

Chronic Fatigue Syndrome in Patients with Deteriorated Iron Metabolism
by: Michał Świątczak, et al.
Published: (2022-08-01)

Left Ventricular Function and Iron Loading Status in a Tertiary Center Hemochromatosis Cohort—A Cardiac Magnetic Resonance Study
by: Karolina Dorniak, et al.
Published: (2022-10-01)

Hypogonadotropic hypogonadism in men with hereditary hemochromatosis
by: Rabih El Osta, et al.
Published: (2017-07-01)

Identification of novel non-HFE mutations in Chinese patients with hereditary hemochromatosis
by: Wei Zhang, et al.
Published: (2022-06-01)

Juvenile Hereditary Hemochromatosis: A Case Report
by: Chhavi GOYAL, et al.
Published: (2025-09-01)

Therapeutic Erythrocytapheresis in the Initial Treatment of Hereditary Hemochromatosis
by: Vít Řeháček, et al.
Published: (2012-01-01)

Left Ventricle Segmental Longitudinal Strain and Regional Myocardial Work Index Could Help Determine Mitral Valve Prolapse Patients with Increased Risk of Ventricular Arrhythmias
by: Ludmiła Daniłowicz-Szymanowicz, et al.
Published: (2023-04-01)

A rare case of porphyria cutanea tarda in a patient with a homozygous hereditary hemochromatosis gene H63D mutation in the setting of hereditary hemochromatosis
by: Jonathan Banta, MD, et al.
Published: (2024-08-01)

Screening for Hereditary Hemochromatosis in Newly Referred Diabetes Mellitus
by: Michael Lockhart, et al.
Published: (2023-12-01)

Idiopathic brain calcification in a patient with hereditary hemochromatosis
by: Stefania Scarlini, et al.
Published: (2020-03-01)

Non-HFE hemochromatosis
by: Paulo Caleb Júnior de Lima Santos, et al.
Published: (2012-01-01)

Comprehensive Echocardiography of Left Atrium and Left Ventricle Using Modern Techniques Helps in Better Revealing Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
by: Elżbieta Wabich, et al.
Published: (2021-07-01)

GNPAT rs11558492 is not a Major Modifier of Iron Status: Study of Italian Hemochromatosis Patients and Blood Donors
by: Federico Greni, et al.
Published: (2017-05-01)

Application and clinical efficacy of red blood cell therapeutic apheresis in erythropoietic protoporphyria and hereditary hemochromatosis
by: LIU Haoqiang, et al.
Published: (2025-07-01)

Hereditary Hemochromatosis Unmasked by Yersiniosis: Report of Three Cases
by: Karam Karam, et al.
Published: (2025-01-01)

TSAT-Urated Insights: Clarifying the Complexities of Hereditary Hemochromatosis and Its Guidelines
by: Chiara Marcon, et al.
Published: (2024-12-01)

Association of HFE genotypes with hemochromatosis-related phenotypes in the All of Us research program
by: Nandana D. Rao, et al.
Published: (2025-01-01)

Isolated Non-Progressive Hemidystonia in a Patient Homozygous for H63D Variant of Hereditary Hemochromatosis: A Case Report and Systematic Literature Review of Movement Disorders in Hereditary Hemochromatosis
by: Stefania Kalampokini, et al.
Published: (2025-09-01)

Case Report: Secukinumab for the treatment of severe psoriasis in a patient with hereditary hemochromatosis
by: Yingzhe Yu, et al.
Published: (2025-08-01)

Infectious Mononucleosis Causing Acute Liver Failure and Hemolytic Anemia in a Patient with Underlying Hereditary Hemochromatosis
by: Mark Forsberg, et al.
Published: (2020-09-01)

Multilocular Hepatic Abscess Formation and Sepsis due to Yersinia enterocolitica in a Patient with Hereditary Hemochromatosis and Type 2 Diabetes Mellitus
by: Matthias Sauter, et al.
Published: (2017-11-01)

Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis
by: Olga Hilda Orasan, et al.
Published: (2018-10-01)

Vascular Aging and Damage in Patients with Iron Metabolism Disorders
by: Krzysztof Młodziński, et al.
Published: (2022-11-01)

Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
by: Jasbir Makker, et al.
Published: (2015-01-01)

Effect of standard phlebotomy on myocardial and hepatic iron levels in newly diagnosed cardiac asymptomatic hereditary hemochromatosis subjects with C282Y homozygosity
by: Yukitaka Shizukuda, et al.
Published: (2023-05-01)

Advances in the application of echocardiography in septic cardiomyopathy
by: LIN Huan*, REN Hongsheng
Published: (2024-11-01)

Frequency of Three Hemochromatosis Gene Mutations in Antalya, Turkey
by: Oztürk S, et al.
Published: (2007-04-01)

Hereditary Hemochromatosis Caused by SUGP2 and DENND3 Mutation in China: A Case Report
by: Huiqing Qiu, et al.
Published: (2024-12-01)

Hemochromatosis and Xeroderma Pigmentosum: Two (Un)Suspicious Neighbors
by: Filipa Monte, et al.
Published: (2021-02-01)

Speckle tracking strain echocardiography: What sonographers need to know!
by: Ashlee M Davis, et al.
Published: (2017-01-01)

Left atrial reservoir strain measurements derived from intracardiac echocardiography in patients with atrial fibrillation: comparison with transthoracic echocardiography
by: Jingru Lin, et al.
Published: (2023-02-01)

Feasibility and reproducibility of speckle tracking echocardiography in routine assessment of the fetal heart in a low-risk population
by: Sacco Adalina, et al.
Published: (2025-05-01)

Hereditary Transthyretin Amyloidosis: How to Differentiate Carriers and Patients Using Speckle-Tracking Echocardiography
by: Daniela Di Lisi, et al.
Published: (2023-12-01)

Relationship Between Left Atrial Strain and Atrial Fibrillation: The Role of Stress Echocardiography
by: Alfredo Mauriello, et al.
Published: (2024-12-01)

The diagnostic value of three-dimensional echocardiography and speckle tracking echocardiography in patients after myocardial infarction with right ventricle involvement (clinical case)
by: M. Yu. Kolesnyk
Published: (2018-12-01)

Atypical juvenile hereditary hemochromatosis onset with positive pancreatic islet autoantibodies diabetes caused by novel mutations in HAMP and overall clinical management
by: Hui‐Xuan Wu, et al.
Published: (2020-12-01)

A farewell to phlebotomy—use of placenta-derived drugs Laennec and Porcine for improving hereditary hemochromatosis without phlebotomy: a case report
by: Yuki Hamada, et al.
Published: (2022-01-01)