A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes

Objective: Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalyzing the formation and rearrangement of disulfide bonds during protein folding. One of the PDI members is the PDI-associated 6 (PDIA6) protein, which has been shown to play a vital role in β-cell dysfunctio...

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Bibliographic Details
Published in:Molecular Metabolism
Main Authors: Nirav Florian Chhabra, Anna–Lena Amend, Aimée Bastidas-Ponce, Sibylle Sabrautzki, Marta Tarquis-Medina, Stephan Sachs, Marina Rubey, Bettina Lorenz-Depiereux, Annette Feuchtinger, Mostafa Bakhti, Heiko Lickert, Gerhard K.H. Przemeck, Martin Hrabě de Angelis
Format: Article
Language:English
Published: Elsevier 2021-12-01
Subjects:
Pdia6
Insulin
Islets
Diabetes
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001812

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