Intra-articular bone marrow mononuclear cell therapy improves lameness from naturally occurring equine osteoarthritis

Osteoarthritis (OA) can be debilitating and is related to impaired resolution of synovial inflammation. Current treatments offer temporary relief of clinical signs, but have potentially deleterious side effects. Bone marrow mononuclear cells (BMNC) are a rich source of macrophage progenitors that ha...

Full description

Bibliographic Details
Published in:	Frontiers in Veterinary Science
Main Authors:	J. Blake Everett, Bruno C. Menarim, Sarah H. Barrett, Sophie H. Bogers, Christopher R. Byron, R. Scott Pleasant, Stephen R. Werre, Linda A. Dahlgren
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	BMNC macrophage osteoarthritis synovitis inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fvets.2023.1256284/full

Similar Items

Fibrous Demineralized Bone Matrix (DBM) Improves Bone Marrow Mononuclear Cell (BMC)-Supported Bone Healing in Large Femoral Bone Defects in Rats
by: René D. Verboket, et al.
Published: (2021-05-01)

The Induced Membrane Technique—The Filling Matters: Evaluation of Different Forms of Membrane Filling with and without Bone Marrow Mononuclear Cells (BMC) in Large Femoral Bone Defects in Rats
by: René D. Verboket, et al.
Published: (2022-03-01)

Advanced nano modification of ecofriendly glauconite clay for high efficiency methylene blue dye adsorption
by: Eman M. Saad, et al.
Published: (2024-10-01)

Refinement of the Lipopolysaccharide-Induced Synovitis Model in Equine Middle Carpal Joints
by: Michael J. S. Duggan, et al.
Published: (2025-08-01)

A Rare Case Report of Fungal Synovitis Presenting as Pigmented Villonodular Synovitis
by: Banyameen Iqbal, et al.
Published: (2024-08-01)

Synovial Fluid Biomarker Profile After Intra-Articular Administration of Neosaxitoxin in Horses: A Feasibility Study
by: Cristóbal Dörner, et al.
Published: (2025-08-01)

Intra‐articular Osteoid Osteoma of the Intermediate Cuneiform Bone Causing Articular Degeneration: A Rare Case and Literature Review
by: Cheng Chen, et al.
Published: (2023-09-01)

Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing.
by: Nicholas J Parkinson, et al.
Published: (2017-01-01)

Synovitis in osteoarthritis: the current state of the problem
by: I. S. Dydykina, et al.
Published: (2021-04-01)

The effect of low dose intra-articular S(+) ketamine on osteoarthritis in rats: an experimental study
by: Eugênio dos Santos Neto, et al.
Published: (2024-05-01)

Control of articular synovitis for bone and cartilage regeneration in rheumatoid arthritis
by: Hiromu Ito, et al.
Published: (2018-04-01)

Intra-articular Localized Haemangioma of the Knee Mimicking Localized Pigmented Villonodular Synovitis: A Case Report
by: Goki-Kamei GK, et al.
Published: (2017-03-01)

Catastrophic complication after intra-articular injection of platelet-rich plasma – Case report
by: Vijay Shetty, et al.
Published: (2024-03-01)

Cytokine status in posttraumatic synovitis on the background of systemic and intra-articular use of NSAID and ozone
by: G. V. Poryadin, et al.
Published: (2020-08-01)

Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
by: Adele Civino, et al.
Published: (2023-05-01)

Impact of intra-articular high-concentration hyaluronic acid administration on the innate immune response in experimental knee osteoarthritis
by: Gabriel Herrero-Beaumont, et al.
Published: (2025-08-01)

Bilateral pigmented villonodular synovitis of the knee
by: Samir H. Shah, et al.
Published: (2015-12-01)

The MCP2 and the wrist plus two extensor compartments are the most affected and responsive joints/tendons out of the US7 score in patients with rheumatoid arthritis-an observational study
by: A. F. Podewski, et al.
Published: (2022-08-01)

Lead synovitis: The important role of radiology on diagnosis and follow-up: Case report
by: Valentina Mejía-Quiñones, MD, et al.
Published: (2022-10-01)

Familial Synovial Hypertrophy: A Case Report
by: Ramin Shayan-Moghadam, et al.
Published: (2023-10-01)

Radiosynovectomy of Painful Synovitis of Knee Joints Due to Rheumatoid Arthritis by Intra-Articular Administration of 177 Lu-Labeled Hydroxyapatite Particulates: First Human Study and Initial Indian Experience
by: Ajit Shinto, et al.
Published: (2015-04-01)

AVAILABILITY OF ARTHROSONOGRAPHY FOR DIAGNOSIS OF SUBCLINIC A L SYNOVITIS IN PATIENTS WITH EARLY GONARTHRITIS (PRELIMINARY DATA)
by: I. E. Bukina, et al.
Published: (2002-04-01)

PAIN SYNDROME IN OSTEOPOROSIS TREATMENT
by: N A Khitrov
Published: (2009-06-01)

Study of clinical and laboratory profile of patients with reactive arthritis in a tertiary healthcare center
by: Harsh Jain, et al.
Published: (2022-08-01)

HISTOPATHOLOGICAL SCALE AND SYNOVITIS ALGORITHM – 15 YEARS OF EXPERIENCE: EVALUATION AND FOLLOWING PROGRESS
by: V. Krenn, et al.
Published: (2017-07-01)

Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation
by: Meaghan N Holub, et al.
Published: (2024-03-01)

Unusual presentation of talonavicular joint pigmented villonodular synovitis: a case report
by: Omid Elahifar, et al.
Published: (2024-02-01)

Efficacy, safety, and synovial effects of intra-articular hyaluronic acid in treating recalcitrant hemophilic arthropathy of knee joint
by: Tsung-Ying Li, et al.
Published: (2019-01-01)

Association Between Power Doppler Ultrasound Signals and Chronic Pain After Total Knee Arthroplasty: A Cross-Sectional Explorative Study
by: Sugimura N, et al.
Published: (2023-08-01)

Recurrence of arthroscopic treatment of pigmented villonodular synovitis of the knee: A systematic review and meta‐analysis
by: Sohrab Keyhani, et al.
Published: (2025-01-01)

High-grade synovitis associates with clinical markers and response to therapy in chronic inflammatory arthritis: post hoc analysis of a synovial biomarkers prospective cohort study
by: Carlo Garaffoni, et al.
Published: (2024-01-01)

Effects of intra-articular injection of platelet-rich plasma on the inflammatory process and histopathological characteristics of cartilage and synovium in animals with osteoarthritis: a systematic review with meta-analysis
by: Homero Garcia-Motta, et al.
Published: (2024-03-01)

A case of multiple giant pigmented villonodular synovitis lesions in the knee
by: Yichen Jia, et al.
Published: (2025-05-01)

Clinical study of moxibustion in the treatment of hip synovitis in children
by: Yan Chen, et al.
Published: (2025-10-01)

Alendronate-associated Polyarticular Synovitis: A Case Report
by: Büşra Şirin, et al.
Published: (2024-04-01)

As a Rare Site of Invasive Fungal Infection, Chronic Granulomatous Aspergillus Synovitis: A Case Report
by: Aylin Canbolat Ayhan, et al.
Published: (2013-06-01)

Synovitis – an inflammation of joints destroying the bone
by: Georg Schett
Published: (2012-10-01)

A Case of Pigmented Villonodular Synovitis (PVNS) of the Knee Joint in a Young Female
by: Kapoor Chirag, et al.
Published: (2016-07-01)

Glanzmann Thrombasthenia Associated with Siderotic Synovitis and Arthropathy: A Case Report
by: Alawad MJ, et al.
Published: (2023-11-01)

Association between Markers of Synovial Inflammation, Matrix Turnover and Symptoms in Knee Osteoarthritis: A Cross-Sectional Study
by: Xiaotian Yang, et al.
Published: (2021-07-01)