Genesis of the Master Circadian Pacemaker in Mice

The suprachiasmatic nucleus (SCN) of the hypothalamus is the central circadian clock of mammals. It is responsible for communicating temporal information to peripheral oscillators via humoral and endocrine signaling, ultimately controlling overt rhythms such as sleep-wake cycles, body temperature, a...

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Bibliographic Details
Published in:Frontiers in Neuroscience
Main Authors: Arthur H. Cheng, Hai-Ying Mary Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Subjects:
suprachiasmatic nucleus
neurogenesis
development
neuronal differentiation
transcription factors
neuropeptides
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.659974/full
Description
Summary:The suprachiasmatic nucleus (SCN) of the hypothalamus is the central circadian clock of mammals. It is responsible for communicating temporal information to peripheral oscillators via humoral and endocrine signaling, ultimately controlling overt rhythms such as sleep-wake cycles, body temperature, and locomotor activity. Given the heterogeneity and complexity of the SCN, its genesis is tightly regulated by countless intrinsic and extrinsic factors. Here, we provide a brief overview of the development of the SCN, with special emphasis on the murine system.
ISSN:1662-453X

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