VKORC1 mutations in rodent populations of a tropical city-state as an indicator of anticoagulant rodenticide resistance

Abstract Anticoagulant rodenticides are commonly used in rodent control because they are economical and have great deployment versatility. However, rodents with Single Nucleotide Polymorphism (SNP) mutations within the Vkorc1 gene are resistant to the effects of anticoagulant rodenticide use and thi...

Full description

Bibliographic Details
Published in:	Scientific Reports
Main Authors:	Cliff Chua, Mahathir Humaidi, Erica Sena Neves, Diyar Mailepessov, Lee Ching Ng, Joel Aik
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-03-01
Online Access:	https://doi.org/10.1038/s41598-022-08653-8

Similar Items

Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats
by: Nuri Yiğit, et al.
Published: (2023-05-01)

Influence of air pollution and climate variability on dengue in Singapore: a time-series analysis
by: Diyar Mailepessov, et al.
Published: (2025-04-01)

Anticoagulant rodenticide poisoning in calves - case report
by: R.A.T. Almeida, et al.
Published: (2024-09-01)

VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites
by: Katrin J. Czogalla, et al.
Published: (2018-03-01)

The use of anticoagulants for rodent control in a mixed-use urban environmefent in Singapore: A controlled interrupted time series analysis.
by: Stacy Soh, et al.
Published: (2022-01-01)

Anticoagulant rodenticides in mesocarnivores around the world: A review
by: David Fernández-Casado, et al.
Published: (2025-01-01)

Anticoagulant Rodenticides Poisonings in Humans and Animals – Short Review
by: Marcin Zawadzki, et al.
Published: (2019-05-01)

Genetic determinants of indirect anticoagulants’ sensitivity: VKORC1 and APOE gene polymorphism
by: D. A. Sychev, et al.
Published: (2005-10-01)

Genetic determinants of indirect anticoagulants’ sensitivity: VKORC1 and APOE gene polymorphism
by: D. A. Sychev, et al.
Published: (2005-10-01)

Thromboelastographic evaluation of coagulation in a dog with anticoagulant rodenticide intoxication
by: ERALP İNAN O, et al.
Published: (2016-05-01)

Anticoagulant rodenticide poisoning in farmed Patagonian mara (Dolichotis patagonum)
by: Piyarat Chansiripornchai, et al.
Published: (2024-03-01)

Does the lower concentration of anticoagulants affect the efficacy of rodenticide baits?
by: Frankova, Marcela, et al.
Published: (2018-11-01)

Anticoagulant rodenticide accumulation in the liver and plasma of pigeons (Columba livia) in Thailand
by: Kosal Phourng, et al.
Published: (2025-08-01)

Effects of Long-Acting Anticoagulant Rodenticides on Rabbit Plasma Extracellular Vesicles
by: Intakhar Ahmad, et al.
Published: (2025-04-01)

First report on the occurrence of anticoagulant rodenticides toxicosis in nontarget animals in Thailand
by: Piyarat Chansiripornchai, et al.
Published: (2025-05-01)

An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils
by: Andrea Acosta-Dacal, et al.
Published: (2021-04-01)

A strategy to improve rodent control while reducing rodenticide release into the environment
by: Tanja Blažić, et al.
Published: (2024-04-01)

Efficacy of Diferent Formulations of Bromodiolone-based Rodenticides Against Rodent Pests in Alfalfa
by: Goran Jokić, et al.
Published: (2010-01-01)

Rodenticides
by: Frederick M. Fishel
Published: (2019-10-01)

Cholestyramine: an inexpensive but overlooked treatment for long-acting anticoagulant rodenticide (LAAR) poisoning
by: Israel Rubinstein, et al.
Published: (2024-12-01)

Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report
by: Yanxi Jia, et al.
Published: (2024-11-01)

Abdominal radiographic features of anticoagulant rodenticide toxicity in 14 dogs and 2 cats
by: Katelyn Hecke, et al.
Published: (2024-06-01)

Unilateral retrobulbar haemorrhage in a cat secondary to suspected anticoagulant rodenticide intoxication
by: Daeyun Seo, et al.
Published: (2024-07-01)

The Genetic Polymorphisms of CYP2C9 and VKORC1 in the Saudi Population and Their Impact on Anticoagulant Management
by: Mohammad Al Hamad
Published: (2025-10-01)

Drivers of anticoagulant rodenticide exposure in fishers (Pekania pennanti) across the northeastern United States
by: Georgianna Silveira, et al.
Published: (2024-02-01)

Isolation and Genetic Characterization of Japanese Encephalitis Virus Two Decades after Its Elimination in Singapore
by: Ming Jie Lim, et al.
Published: (2022-11-01)

Use of anticoagulant rodenticides: a silent threat to biodiversity in a city of Northern Colombian Andes
by: María Antonia Jaramillo-Q., et al.
Published: (2024-11-01)

Widespread Contamination by Anticoagulant Rodenticides in Insectivorous Wildlife from the Canary Islands: Exploring Alternative Routes of Exposure
by: Beatriz Martín Cruz, et al.
Published: (2025-06-01)

Impact of changes in governance for anticoagulant rodenticide use on non-target exposure in red foxes (Vulpes vulpes)
by: S. Campbell, et al.
Published: (2024-01-01)

Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum
by: Ankur Naqib, et al.
Published: (2025-12-01)

Unmet clinical laboratory need in patients hospitalized for acute poisoning from long-acting anticoagulant rodenticides
by: Richard B. van Breemen, et al.
Published: (2021-11-01)

Inhaled synthetic cannabinoids laced with long-acting anticoagulant rodenticides: a clear and present worldwide danger
by: Douglas L. Feinstein, et al.
Published: (2022-12-01)

Comparison of efficacy of second-generation anticoagulant rodenticides: Effect of active ingredients, type of formulation and commercial suppliers
by: Olga V. Suárez, et al.
Published: (2018-01-01)

Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore
by: Meng Han Lee, et al.
Published: (2023-01-01)

Anticoagulant rodenticide exposure and toxicosis in bald eagles (Haliaeetus leucocephalus) and golden eagles (Aquila chrysaetos) in the United States.
by: Kevin D Niedringhaus, et al.
Published: (2021-01-01)

Anticoagulant rodenticides on our public and community lands: spatial distribution of exposure and poisoning of a rare forest carnivore.
by: Mourad W Gabriel, et al.
Published: (2012-01-01)

The c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use
by: Kovač Mirjana, et al.
Published: (2009-01-01)

Establishment of Acenocoumarol Pharmacogenetic Algorithm Including CYP2C9 and VKORC1 Genotypes in Bulgarian Patients Treated with Coumarin Anticoagulants
by: Tzveova R., et al.
Published: (2025-06-01)

Correction: Anticoagulant rodenticide exposure and toxicosis in bald eagles (Haliaeetus leucocephalus) and golden eagles (Aquila chrysaetos) in the United States
Published: (2025-01-01)

Correction: Anticoagulant rodenticide exposure and toxicosis in bald eagles (Haliaeetus leucocephalus) and golden eagles (Aquila chrysaetos) in the United States.
by: Kevin D Niedringhaus, et al.
Published: (2025-01-01)