Urinary proteome profiles associated with cognitive decline in community elderly residents—A pilot study

Non-invasive and simple methods enabling easy identification of individuals at high risk of cognitive decline are needed as preventive measures against dementia. This pilot study aimed to explore protein biomarkers that can predict cognitive decline using urine, which can be collected non-invasively...

Full description

Bibliographic Details
Published in:	Frontiers in Neurology
Main Authors:	Yumi Watanabe, Yoshitoshi Hirao, Kensaku Kasuga, Kaori Kitamura, Kazutoshi Nakamura, Tadashi Yamamoto
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	urine cognitive decline dementia biomarker proteomics
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2023.1134976/full

Similar Items

Molecular Network Analysis of the Urinary Proteome of Alzheimer’s Disease Patients
by: Yumi Watanabe, et al.
Published: (2019-02-01)

Changes in the urinary proteome in rats with regular swimming exercise
by: Wenshu Meng, et al.
Published: (2021-11-01)

Comparison of urinary proteome in the first two days after mating in male rats
by: Haitong Wang, et al.
Published: (2024-01-01)

Urinary biomarker discovery in gliomas using mass spectrometry-based clinical proteomics
by: Jianqiang Wu, et al.
Published: (2020-04-01)

Cerebrospinal Fluid Proteome Alterations Associated with Neuropsychiatric Symptoms in Cognitive Decline and Alzheimer’s Disease
by: Magdalena Mroczek, et al.
Published: (2022-03-01)

Proteome Profiling of Diabetic Mellitus Patient Urine for Discovery of Biomarkers by Comprehensive MS-Based Proteomics
by: Yoshitoshi Hirao, et al.
Published: (2018-02-01)

Differential diagnosis for cognitive decline in elderly
by: Om Prakash, et al.
Published: (2016-01-01)

Dynamic urinary proteomic analysis in a Walker 256 intracerebral tumor model
by: Linpei Zhang, et al.
Published: (2019-07-01)

Non-invasive urinary proteomic biomarkers for prognostic assessment in sepsis
by: Qingbo Zeng, et al.
Published: (2025-07-01)

Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction
by: Corinne Carland, et al.
Published: (2024-05-01)

Changes in the urinary proteome before and after quadrivalent influenza vaccine and COVID-19 vaccination
by: Xuanzhen Pan, et al.
Published: (2022-10-01)

Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT)
by: Ziyun Shen, et al.
Published: (2023-12-01)

Urinary proteomics evaluation in interstitial cystitis/painful bladder syndrome: a pilot study
by: Young Ah Goo, et al.
Published: (2010-08-01)

Urinary Proteome and Exosome Analysis Protocol for the Discovery of Respiratory Diseases Biomarkers
by: Laura Martelo-Vidal, et al.
Published: (2025-01-01)

Beauvoir’s Concept of “Decline”
by: Matthew R. McLennan
Published: (2020-09-01)

Effects of anesthetics pentobarbital sodium and chloral hydrate on urine proteome
by: Mindi Zhao, et al.
Published: (2015-03-01)

Investigating and Annotating the Human Peptidome Profile from Urine under Normal Physiological Conditions
by: Amr Elguoshy, et al.
Published: (2024-06-01)

Factors influencing the deterioration from cognitive decline of normal aging to dementia among nursing home residents
by: Audai A. Hayajneh, et al.
Published: (2020-11-01)

Urinary Proteome Differences in Canine Diabetes with and without the Presence of Microalbuminuria
by: Dagmara Winiarczyk, et al.
Published: (2022-03-01)

Steeper memory decline after COVID-19 lockdown measures
by: Els D. Bakker, et al.
Published: (2023-04-01)

Design of the Swiss Atrial Fibrillation Cohort Study (Swiss-AF): structural brain damage and cognitive decline among patients with atrial fibrillation
by: David Conen, et al.
Published: (2017-07-01)

Effects of arginine vasopressin on the urine proteome in rats
by: Manxia An, et al.
Published: (2017-05-01)

Comparison of urine proteomes from tumor-bearing mice with those from tumor-resected mice
by: Ziqi Heng, et al.
Published: (2023-01-01)

Urinary Sediment Transcriptomic and Longitudinal Data to Investigate Renal Function Decline in Type 1 Diabetes
by: Maria Beatriz Monteiro, et al.
Published: (2020-04-01)

Plasma proteomic signatures of dual cognitive and mobility decline in older adultsResearch in context
by: Qu Tian, et al.
Published: (2025-08-01)

Research of Prostate Cancer Urinary Diagnostic Biomarkers by Proteomics: The Noteworthy Influence of Inflammation
by: Elisa Bellei, et al.
Published: (2023-04-01)

Association between nutritional status and cognitive decline in non-institutionalized elderly patients evaluated in a geriatric outpatient setting
by: Raffaele Pagliuca, et al.
Published: (2023-05-01)

Antidepressant use and cognitive decline in patients with dementia: a national cohort study
by: Minjia Mo, et al.
Published: (2025-02-01)

Early changes in the urine proteome in a rat liver tumour model
by: Yameng Zhang, et al.
Published: (2020-02-01)

Urinary Biomarkers of Brain Diseases
by: Manxia An, et al.
Published: (2015-12-01)

The efficacy and practicality of the Neurotrack Cognitive Battery assessment for utilization in clinical settings for the identification of cognitive decline in an older Japanese population
by: Jordan M. Glenn, et al.
Published: (2023-08-01)

Demand Coupling Drives Neurodegeneration: A Model of Age-Related Cognitive Decline and Dementia
by: Josh Turknett, et al.
Published: (2022-09-01)

Urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells
by: Jing Wei, et al.
Published: (2019-09-01)

Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics
by: Liu-Yun Wu, et al.
Published: (2022-08-01)

Does the Urinary Proteome Reflect ccRCC Stage and Grade Progression?
by: Lucia Santorelli, et al.
Published: (2021-12-01)

Reducing the Risk of Cognitive Decline and Dementia: WHO Recommendations
by: Neerja Chowdhary, et al.
Published: (2022-01-01)

Migraine headaches as a preliminary symptom for cognitive decline
by: Ahad Hasan Syed Hasani, et al.
Published: (2023-01-01)

Urinary proteome analysis using capillary electrophoresis coupled to mass spectrometry: A powerful tool in clinical diagnosis, prognosis and therapy evaluation
by: Mischak Harald, et al.
Published: (2009-01-01)

Application of preparative electrophoresis for clinical proteomics in urine: Is it feasible?
by: Zoidakis Jérôme, et al.
Published: (2009-01-01)

Subjective cognitive decline: The first clinical manifestation of Alzheimer's disease?
by: Adalberto Studart Neto, et al.