M2 microglia-derived exosomes reduce neuronal ferroptosis via FUNDC1-mediated mitophagy by activating AMPK/ULK1 signaling

Abstract Neuronal ferroptosis plays a vital role in the progression of neonatal hypoxic-ischemic brain damage (HIBD). M2-type microglia-derived exosomes (M2-exos) have been shown to protect neurons from ischemia–reperfusion (I/R) brain injury, but their impact on I/R-induced neuronal ferroptosis and...

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Bibliographic Details
Published in:	Scientific Reports
Main Authors:	Jian Li, Qing Chen, Hao Gu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Subjects:	Microglia Exosome Ferroptosis Mitophagy Ischemia/reperfusion
Online Access:	https://doi.org/10.1038/s41598-025-03091-8

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