THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathway
Abstract Colorectal cancer (CRC) is the most common human digestive malignancy with a poor prognosis; the pathophysiology of colon cancer involves multiple linkages of regulatory networks. Recently, thrombospondin 2 (THBS2) has been extensively studied for its role in cancer progression. In this stu...
| الحاوية / القاعدة: | Kaohsiung Journal of Medical Sciences |
|---|---|
| المؤلفون الرئيسيون: | , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Wiley
2022-05-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1002/kjm2.12528 |
| _version_ | 1852645848993759232 |
|---|---|
| author | Hong‐Lan Qu Gao‐Wa Hasen Yan‐Yan Hou Chun‐Xia Zhang |
| author_facet | Hong‐Lan Qu Gao‐Wa Hasen Yan‐Yan Hou Chun‐Xia Zhang |
| author_sort | Hong‐Lan Qu |
| collection | DOAJ |
| container_title | Kaohsiung Journal of Medical Sciences |
| description | Abstract Colorectal cancer (CRC) is the most common human digestive malignancy with a poor prognosis; the pathophysiology of colon cancer involves multiple linkages of regulatory networks. Recently, thrombospondin 2 (THBS2) has been extensively studied for its role in cancer progression. In this study, we evaluated the expression of THBS2 in CRC tissues and studied the possible mechanism by which THBS2 regulates CRC progression. Our results showed that the upregulation of THBS2 in CRC tissues and CRC cell lines and high expression of THBS2 was correlated with poor overall survival. The in vitro experimental data showed that THBS2 overexpression promoted CRC cell growth, invasion, and migration, while THBS2 inhibition exerted tumor‐suppressive actions on CRC cells. THBS2 knockdown suppressed the activity of Wnt/β‐catenin signaling. Collectively, the results implied that THBS2 exerted promotional effects on CRC cell proliferation, invasion, and migration, partly by modulating the Wnt/β‐catenin signaling pathway. |
| format | Article |
| id | doaj-art-d64ca0c4ee0d4e7dbd46c41abea974be |
| institution | Directory of Open Access Journals |
| issn | 1607-551X 2410-8650 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| spelling | doaj-art-d64ca0c4ee0d4e7dbd46c41abea974be2025-08-19T21:43:00ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502022-05-0138546947810.1002/kjm2.12528THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathwayHong‐Lan Qu0Gao‐Wa Hasen1Yan‐Yan Hou2Chun‐Xia Zhang3Department of Hematology and Oncologycology Inner Mongolia Forestry General Hospital (The Second Clinical Medical College of Inner Mongolia University for Nationalities) Inner Mongolia ChinaDepartment of Hematology and Oncologycology Inner Mongolia Forestry General Hospital (The Second Clinical Medical College of Inner Mongolia University for Nationalities) Inner Mongolia ChinaDepartment of Hematology and Oncologycology Inner Mongolia Forestry General Hospital (The Second Clinical Medical College of Inner Mongolia University for Nationalities) Inner Mongolia ChinaDepartment of Gastroenterology Inner Mongolia Forestry General Hospital (The Second Clinical Medical College of Inner Mongolia University for Nationalities) Inner Mongolia ChinaAbstract Colorectal cancer (CRC) is the most common human digestive malignancy with a poor prognosis; the pathophysiology of colon cancer involves multiple linkages of regulatory networks. Recently, thrombospondin 2 (THBS2) has been extensively studied for its role in cancer progression. In this study, we evaluated the expression of THBS2 in CRC tissues and studied the possible mechanism by which THBS2 regulates CRC progression. Our results showed that the upregulation of THBS2 in CRC tissues and CRC cell lines and high expression of THBS2 was correlated with poor overall survival. The in vitro experimental data showed that THBS2 overexpression promoted CRC cell growth, invasion, and migration, while THBS2 inhibition exerted tumor‐suppressive actions on CRC cells. THBS2 knockdown suppressed the activity of Wnt/β‐catenin signaling. Collectively, the results implied that THBS2 exerted promotional effects on CRC cell proliferation, invasion, and migration, partly by modulating the Wnt/β‐catenin signaling pathway.https://doi.org/10.1002/kjm2.12528colon cancerinvasionmigrationTHBS2Wnt/β‐catenin |
| spellingShingle | Hong‐Lan Qu Gao‐Wa Hasen Yan‐Yan Hou Chun‐Xia Zhang THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathway colon cancer invasion migration THBS2 Wnt/β‐catenin |
| title | THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathway |
| title_full | THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathway |
| title_fullStr | THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathway |
| title_full_unstemmed | THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathway |
| title_short | THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β‐catenin signaling pathway |
| title_sort | thbs2 promotes cell migration and invasion in colorectal cancer via modulating wnt β catenin signaling pathway |
| topic | colon cancer invasion migration THBS2 Wnt/β‐catenin |
| url | https://doi.org/10.1002/kjm2.12528 |
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