Personalized digital intervention for depression based on social rhythm principles adds significantly to outpatient treatment

We conducted a 16-week randomized controlled trial in psychiatric outpatients with a lifetime diagnosis of a mood and/or anxiety disorder to measure the impact of a first-of-its-kind precision digital intervention software solution based on social rhythm regulation principles. The full intent-to-tre...

Full description

Bibliographic Details
Published in:	Frontiers in Digital Health
Main Authors:	Ellen Frank, Meredith L. Wallace, Mark J. Matthews, Jeremy Kendrick, Jeremy Leach, Tara Moore, Gabriel Aranovich, Tanzeem Choudhury, Nirav R. Shah, Zeenia Framroze, Greg Posey, Samuel A. Burgess, David J. Kupfer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	depression treatment digital intervention platform passive monitoring depressive symptoms social rhythm disruption
Online Access:	https://www.frontiersin.org/articles/10.3389/fdgth.2022.870522/full

Similar Items

A translationally informed approach to vital signs for psychiatry: a preliminary proof of concept
by: Meredith L. Wallace, et al.
Published: (2024-08-01)

Ketamine as Add-On Treatment in Psychotic Treatment-Resistant Depression
by: Maria Gałuszko-Węgielnik, et al.
Published: (2023-01-01)

Measuring algorithmic bias to analyze the reliability of AI tools that predict depression risk using smartphone sensed-behavioral data
by: Daniel A. Adler, et al.
Published: (2024-04-01)

Acupuncture as Add-on Therapy to SSRIs Can Improve Outcomes of Treatment for Anxious Depression: Subgroup Analysis of the AcuSDep Trial
by: Zhao B, et al.
Published: (2024-05-01)

Insomnia and Esketamine Add-On Therapy to Antidepressant Therapy in Patients with Treatment-Resistant Depression—A Pilot Study
by: Daniel Szawarnoga, et al.
Published: (2025-07-01)

Central nervous system-related safety and tolerability of add-on ketamine to standard of care treatment in treatment-resistant psychotic depression in patients with major depressive disorder and bipolar disorder
by: Maria Gałuszko-Wȩgielnik, et al.
Published: (2023-07-01)

Machine learning for passive mental health symptom prediction: Generalization across different longitudinal mobile sensing studies.
by: Daniel A Adler, et al.
Published: (2022-01-01)

Perceived Neighborhood Social Environment and Adolescent Depressive Symptoms: Insights from the Add Health
by: Rachel J. Kulchar, et al.
Published: (2024-12-01)

Randomised controlled trial of Antiglucocorticoid augmentation (metyrapone) of antiDepressants in Depression (ADD Study)
by: I Nicol Ferrier, et al.
Published: (2015-06-01)

Associations of Rest‐Activity Rhythm Disturbances With Stroke Risk and Poststroke Adverse Outcomes
by: Lei Gao, et al.
Published: (2024-09-01)

Cold water swimming as an add-on treatment for depression. A feasibility study
by: P. Hjorth, et al.
Published: (2022-06-01)

A pilot study on high amplitude low frequency–music impulse stimulation as an add‐on treatment for depression
by: Gudrun Agusta Sigurdardóttir, et al.
Published: (2019-10-01)

Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms
by: Mírian C.M.M. David, et al.
Published: (2022-10-01)

Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study
by: Victoria Omranifard, et al.
Published: (2014-01-01)

The blues and rhythm
by: Kiyomichi Imamura, et al.
Published: (2025-02-01)

THE USABILITY OF ADD-ON TRANSCRANIAL DIRECT CURRENT STIMULATION IN MAINTENANCE NEUROMODULATION TREATMENTS – A CASE SERIES
by: SIIRI KILPELÄINEN, SAANA KARTTUNEN, MATIAS LEPPÄAHO, ERFAN JAHANGIRI, LIISA KANTOJÄRVI, MARIANNE HAAPEA, ERIKA JÄÄSKELÄINEN
Published: (2025-10-01)

Stereotactic Radiofrequency Ablation for Treatment-Refractory Depression: A Systematic Review and Meta-Analysis
by: Pauline Sarah Münchenberg, et al.
Published: (2022-10-01)

Bibliometric and visual analysis of circadian rhythms in depression from 2004 to 2024
by: Cong Zhou, et al.
Published: (2025-05-01)

Effect of Anxiety, Depression, and Anxiety Sensitivity on Learning Performance in Rhythm Training
by: Sibel Karaman, et al.
Published: (2024-06-01)

Biological Rhythms and Psychosocial Functioning in Depression: An Exploratory Analysis Informed by a Mediation Model
by: Claudia Savia Guerrera, et al.
Published: (2025-07-01)

Impact of yoga breathing and relaxation as an add-on therapy on quality of life, anxiety, depression and pulmonary function in young adults with bronchial asthma: A randomized controlled trial
by: M.J. Sangeethalaxmi, et al.
Published: (2023-01-01)

Interest in a short psychological intervention in patients with psoriasis: a cross-sectional observational study at a German clinic
by: Laura R. Stadtmüller, et al.
Published: (2023-06-01)

Understanding Mental Health Clinicians’ Perceptions and Concerns Regarding Using Passive Patient-Generated Health Data for Clinical Decision-Making: Qualitative Semistructured Interview Study
by: Jodie Nghiem, et al.
Published: (2023-08-01)

The Relationship between Anxiety, Subjective and Objective Sleep, Chronotype and Circadian Rhythms with Depressive Symptoms in Insomnia Disorder
by: Maria Comas, et al.
Published: (2023-04-01)

Preferences of young adults on the development of a new digital add-on alcohol intervention for depression treatment: A qualitative study
by: Maria J.E. Schouten, et al.
Published: (2023-09-01)

Effects of Exercise in People with Severe Mental Illness and Recommendations for its Implementation as Add-on Therapy
by: I. Maurus, et al.
Published: (2022-06-01)

Molecular basis for the association between depression and circadian rhythm
by: Peeraporn Varinthra, et al.
Published: (2019-01-01)

Changes of adrenocorticotropic hormone rhythm and cortisol circadian rhythm in patients with depression complicated with anxiety and their effects on the psychological state of patients
by: Zheng Xie, et al.
Published: (2023-01-01)

A call for open data to develop mental health digital biomarkers
by: Daniel A. Adler, et al.
Published: (2022-03-01)

Evaluation of a web-based information platform on youth depression and mental health in parents of adolescents with a history of depression
by: Lucia Iglhaut, et al.
Published: (2024-01-01)

Evidence-Based Pharmacotherapy of Anxiety Symptoms in Patients with Major Depressive Disorder: Focus on Agomelatine
by: Dan J. Stein
Published: (2023-04-01)

Digital biomarker of mental fatigue
by: Vincent Wen-Sheng Tseng, et al.
Published: (2021-03-01)

Treating with esketamine nasal, will increase blood pressure?
by: V. Rosello-Molina, et al.
Published: (2021-04-01)

Randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of selective serotonin reuptake inhibitors plus supportive care, versus supportive care alone, for mild to moderate depression with somatic symptoms in primary care: the THREAD (THREshold for AntiDepressant response) study
by: T Kendrick, et al.
Published: (2009-04-01)

Vitamin-mediated interaction between the gut microbiome and mitochondria in depression: A systematic review-based integrated perspective
by: Ellen Bisle, et al.
Published: (2024-07-01)

Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression
by: Soraia Silva, et al.
Published: (2021-11-01)

Stress Appraisals and Coping across and within Academic, Parent, and Peer Stressors: The Roles of Adolescents’ Emotional Problems, Coping Flexibility, and Age
by: Melanie J. Zimmer-Gembeck, et al.
Published: (2024-02-01)

Add-On Intermittent Theta Burst Stimulation Improves the Efficacy of First-Episode and Recurrent Major Depressive Disorder: Real-World Clinical Practice
by: Li G, et al.
Published: (2023-01-01)

Transcendental Meditation for women affected by domestic violence: Study protocol of a pilot randomised, controlled trial
by: Matthew J. Leach, et al.
Published: (2020-12-01)

Translation Effectiveness of Offset Heart Rate Biofeedback as a Mindless Intervention for Alcohol Craving Among Risky Drinkers: Controlled Experiment
by: Yiran Zhao, et al.
Published: (2024-12-01)