Establishment of a non-integrated iPS cell line (SDQLCHi072-A) from a patient suffered from AUTS2 syndrome

In this study, PBMCs used in reprogramming were from a boy suffered from AUTS2 syndrome confirmed by clinical and genetic diagnosis. iPSCs were established by non-integrated method, which carried AUTS2 heterozygous mutation. The established iPSCs presented similar appearance and expressed pluripoten...

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Bibliographic Details
Published in:Stem Cell Research
Main Authors: Zilong Li, Zhengbin Li, Yuqiang Lv, Min Gao, Ning Liu, Zhongtao Gai, Qiji Liu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Subjects:
iPSC
Reprogramming
AUTS2
AUTS2 syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506124002526
Description
Summary:In this study, PBMCs used in reprogramming were from a boy suffered from AUTS2 syndrome confirmed by clinical and genetic diagnosis. iPSCs were established by non-integrated method, which carried AUTS2 heterozygous mutation. The established iPSCs presented similar appearance and expressed pluripotent markers in mRNA and protein level. Additionally, the iPSCs possessed favorable differentiative capacity in vivo and normal karyotype. This is an effective potential model for the study about AUTS2 syndrome and the screen about drug therapy.
ISSN:1873-5061

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