Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer

Background: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. Method: Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis t...

Full description

Bibliographic Details
Published in:	EBioMedicine
Main Authors:	Lingjian Yang, Darren Roberts, Mandeep Takhar, Nicholas Erho, Becky A.S. Bibby, Niluja Thiruthaneeswaran, Vinayak Bhandari, Wei-Chen Cheng, Syed Haider, Amy M.B. McCorry, Darragh McArt, Suneil Jain, Mohammed Alshalalfa, Ashley Ross, Edward Schaffer, Robert B. Den, R. Jeffrey Karnes, Eric Klein, Peter J. Hoskin, Stephen J. Freedland, Alastair D. Lamb, David E. Neal, Francesca M. Buffa, Robert G. Bristow, Paul C. Boutros, Elai Davicioni, Ananya Choudhury, Catharine M.L. West
Format:	Article
Language:	English
Published:	Elsevier 2018-05-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396418301476

Similar Items

“Thus, I Give Up the Spear!”: Sovereignty and Violence against Animals
by: Seán McCorry
Published: (2016-03-01)

Ecological effects of <i>Spartina anglica</i> on the macro-invertebrate infauna of the mud flats at Bull Island, Dublin Bay, Ireland
by: M. L. Otte, et al.
Published: (2001-10-01)

Does radiation-induced lymphocytopenia matter? Developing a radiotherapy dosimetric strategy for immune preservation and improved survival
by: John Conibear, et al.
Published: (2025-08-01)

Exploring the understanding of best practice approaches to common dog behaviour problems by veterinary professionals in Ireland
by: Emma Shalvey, et al.
Published: (2019-03-01)

A note from the Editor in Chief of JDS Communications: Our purpose and people
by: Jessica A.A. McArt
Published: (2024-11-01)

JDS Communications® 2024 Editorial Report
by: Jessica A.A. McArt
Published: (2025-03-01)

A note from the Editor in Chief of JDS Communications: The challenge of brevity for authors and reviewers
by: Jessica A.A. McArt
Published: (2024-07-01)

JDS Communications special issue: Behavior in Dairy Animals—Introduction
by: Jessica A.A. McArt
Published: (2024-09-01)

JDS Communications H5N1 special issue: The importance of collaboration
by: Jessica A.A. McArt
Published: (2024-10-01)

A note from the Editor in Chief of JDS Communications: Elevating science via social media
by: Jessica A.A. McArt
Published: (2024-03-01)

A note from the JDS Communications Editor in Chief
by: Jessica A.A. McArt
Published: (2024-01-01)

Efficacy of internal and external teat sealants on cure and new infection risk in dry-off protocols for Holstein cows
by: J.A.A. McArt, et al.
Published: (2024-11-01)

A note from the Editor in Chief of JDS Communications: Connecting via coffee and ice cream
by: JessicaA.A. McArt, Editor in Chief
Published: (2024-05-01)

Identifying models of delivery, care domains and quality indicators relevant to palliative day services: a scoping review protocol
by: Seán R. O’Connor, et al.
Published: (2017-05-01)

High folate receptor expression is associated with aggressive features in prostate cancer with low prostate‐specific membrane antigen expression
by: Ashorne K. Mahenthiran, et al.
Published: (2026-05-01)

Patterns of periparturient rumination and activity time in multiparous Holstein cows with and without dyscalcemia in early lactation
by: C.R. Seely, et al.
Published: (2024-07-01)

Circulating parathyroid hormone and serotonin in multiparous cows with differing postparturient serum calcium concentrations
by: C.R. Seely, et al.
Published: (2023-12-01)

Blood calcium as a prognostic indicator of success after surgical correction of left displaced abomasum
by: K.D. Bach, et al.
Published: (2021-07-01)

The association of subclinical hypocalcemia at 4 days in milk with reproductive outcomes in multiparous Holstein cows
by: C.R. Seely, et al.
Published: (2023-03-01)

Perspective: Transient postparturient hypocalcemia—A lactation-induced phenomenon of high-producing dairy cows
by: Laura L. Hernandez, et al.
Published: (2023-12-01)

Announcing the ADSA Loyalty Program and other developments
by: Paul J. Kononoff, et al.
Published: (2024-01-01)

Announcing the ADSA Loyalty Program and other developments
by: Paul J. Kononoff, et al.
Published: (2024-01-01)

Erratum to “Blood calcium as a prognostic indicator of success after surgical correction of left displaced abomasum” (JDS Commun. 2:207–211)
by: K.D. Bach, et al.
Published: (2022-03-01)

Plant defenses and predation risk differentially shape patterns of consumption, growth, and digestive efficiency in a guild of leaf-chewing insects.
by: Ian Kaplan, et al.
Published: (2014-01-01)

Efficacy and safety of the pudendal nerve block as a component of multimodal analgesia for cervical brachytherapy
by: Matthew Charles Knox, et al.
Published: (2025-09-01)

Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report
by: Hyun Kim, et al.
Published: (2016-11-01)

Evaluation of Sample Handling Effects on Serum Vitamin E and Cholesterol Concentrations in Alpacas
by: Andrea S. Lear, et al.
Published: (2014-01-01)

Genomic ‘dark matter’ in prostate cancer: exploring the clinical utility of non-exonic ncRNA as biomarkers
by: Ismael A Vergara, et al.
Published: (2012-02-01)

Exploring the experiences of residents and their families in an alcohol-related brain injury residential rehabilitation unit in Northern Ireland: a qualitative study
by: Anne Campbell, et al.
Published: (2024-11-01)

Upscaling methane fluxes from peatlands across a drainage gradient in Ireland using PlanetScope imagery and machine learning tools
by: Ruchita Ingle, et al.
Published: (2023-07-01)

Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy.
by: Nicholas Erho, et al.
Published: (2013-01-01)

Does knowledge of blood calcium concentration at 2 days postpartum affect decisions of calcium supplementation?
by: H.A. McCray, et al.
Published: (2024-05-01)

Research on the perspectives of people affected by dementia with Lewy bodies: a scoping review
by: Paula Sinead Donnelly, et al.
Published: (2025-05-01)

Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis.
by: Clare M McCourt, et al.
Published: (2013-01-01)

Acute phase responses in clinically healthy multiparous Holsteins with and without calcium dysregulation during the early postpartum period
by: J.A. Seminara, et al.
Published: (2025-02-01)

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data.
by: Darragh G McArt, et al.
Published: (2013-01-01)

Co-producing a shared understanding and definition of empowerment with people with dementia
by: Tracey McConnell, et al.
Published: (2019-06-01)

Effects of timing of oral calcium administration on milk production in high-producing early-lactation Holstein cows
by: C.R. Seely, et al.
Published: (2024-03-01)

Diurnal variation of milk fatty acids in early-lactation Holstein cows with and without hyperketonemia
by: C.R. Seely, et al.
Published: (2022-06-01)

A randomized field trial assessing the timing of postpartum calcium bolus administration on milk yield of multiparous Holstein cows
by: E. Mahjoubi, et al.
Published: (2023-10-01)