Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level

During nephrogenesis, stem/progenitor cells differentiate and give rise to early nephron structures that segment to proximal and distal nephron cell types. Previously, we prospectively isolated progenitors from human fetal kidney (hFK) utilizing a combination of surface markers. However, upon cultur...

Full description

Bibliographic Details
Published in:	Stem Cell Reports
Main Authors:	Naomi Pode-Shakked, Rotem Gershon, Gal Tam, Dorit Omer, Yehudit Gnatek, Itamar Kanter, Sarit Oriel, Guy Katz, Orit Harari-Steinberg, Tomer Kalisky, Benjamin Dekel
Format:	Article
Language:	English
Published:	Elsevier 2017-07-01
Subjects:	stem cells kidney stem/progenitor cells renal development stem cell markers Wilms' tumor single cell gene expression analysis cancer stem cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671117301807

Similar Items

Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease
by: Orit Harari‐Steinberg, et al.
Published: (2013-09-01)

The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets†
by: Naomi Pode‐Shakked, et al.
Published: (2012-12-01)

Peroxisome proliferator‐activated receptor gamma (PPARγ) is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target
by: Oren Pleniceanu, et al.
Published: (2017-03-01)

OSR1 and SIX2 drive divergent transcriptional programs in human kidney cells: implications for regeneration and tumorigenesis
by: Naomi Pode-Shakked, et al.
Published: (2025-10-01)

Establishing a technique for isolation and characterization of human periodontal ligament derived mesenchymal stem cells
by: Spoorthi Ravi Banavar, et al.
Published: (2021-11-01)

SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells
by: Mina N.F. Morcos, et al.
Published: (2017-06-01)

Mouse Embryonic Stem Cell-Derived Ureteric Bud Progenitors Induce Nephrogenesis
by: Zenglai Tan, et al.
Published: (2020-01-01)

Transcriptomic analysis of neural stem and progenitor cells in comparison with glioblastoma stem cells
by: V. E. Shevchenko, et al.
Published: (2023-12-01)

The Relevance of Circadian Clocks to Stem Cell Differentiation and Cancer Progression
by: Astha Malik, et al.
Published: (2022-03-01)

Bronchioalveolar stem cells derived from mouse-induced pluripotent stem cells promote airway epithelium regeneration
by: Naoya Kawakita, et al.
Published: (2020-10-01)

SoxB, cell cycle and neurogenesis
by: Theodoros eKarnavas, et al.
Published: (2013-10-01)

STIM-ulation for the big trial
by: Christian Arno Arranto
Published: (2012-07-01)

The application and progress of stem cells in auricular cartilage regeneration: a systematic review
by: Yu Liu, et al.
Published: (2023-07-01)

Counting blood precursors
by: Sarah Duchamp de Chastaigne, et al.
Published: (2024-07-01)

Expression and localization of tight junction-related proteins in adult rat pituitary stem/progenitor cell niches
by: Saishu YOSHIDA, et al.
Published: (2022-04-01)

The Effects of Co-Culture of Embryonic Stem Cells with Neural Stem Cells on Differentiation
by: Ye Rim Kim, et al.
Published: (2022-12-01)

The Elusive Endometrial Epithelial Stem/Progenitor Cells
by: Fiona L. Cousins, et al.
Published: (2021-04-01)

Donor and recipient hematopoietic stem and progenitor cells mobilization in liver transplantation patients
by: Yao Zhi, et al.
Published: (2024-07-01)

The vascular microenvironment and its stem cells regulate vascular homeostasis
by: Yanhui Wang, et al.
Published: (2025-03-01)

PAX6 Expression Patterns in the Adult Human Limbal Stem Cell Niche
by: Naresh Polisetti, et al.
Published: (2023-01-01)

Combination of Stem Cells and Rehabilitation Therapies for Ischemic Stroke
by: Reed Berlet, et al.
Published: (2021-09-01)

Early lymphocyte development in bone marrow and thymus
by: AG Rolink, et al.
Published: (2006-11-01)

A novel Frizzled 7 antibody disrupts the Wnt pathway and inhibits Wilms tumor growth
by: Einav Vax, et al.
Published: (2025-09-01)

Hepatic stellate cells and their role in the formation of the progenitor cell niche
by: V. V. Zhdanov, et al.
Published: (2024-04-01)

Sheng Xue Ning as a Novel Agent that Promotes SCF-Driven Hematopoietic Stem/Progenitor Cell Proliferation to Promote Erythropoiesis
by: Yueying Zeng, et al.
Published: (2024-09-01)

TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone
by: Lingyan Fang, et al.
Published: (2023-06-01)

Clinical potentials of human pluripotent stem cells in lung diseases
by: Yuan Quan, et al.
Published: (2014-12-01)

Characterization of neural stem cells derived from human stem cells from the apical papilla undergoing three-dimensional neurosphere induction
by: Anupong Thongklam SONGSAAD, et al.
Published: (2023-11-01)

Transcoronary stem cell transfer and evolution of infarct-related artery atherosclerosis: evaluation with conventional and novel imaging techniques including Quantitative Virtual Histology (qVH)
by: Wladyslaw Dabrowski, et al.
Published: (2023-02-01)

PAX3 expression patterns in ocular surface melanocytes
by: Eva Ulrich, et al.
Published: (2025-04-01)

Implementation of an ISBT 128-Compatible Medical Record System to Facilitate Traceability of Stem Cell Products
by: Can Boğa, et al.
Published: (2017-08-01)

Improving the viability of tissue‐resident stem cells using an organ‐preservation solution
by: Takaya Suzuki, et al.
Published: (2019-12-01)

Human Cardiac-Derived Stem/Progenitor Cells Fine-Tune Monocyte-Derived Descendants Activities toward Cardiac Repair
by: Noémie Dam, et al.
Published: (2017-10-01)

Advances in Classification and Research Methods of Lung Epithelial Stem  and Progenitor Cells
by: Minhua DENG, et al.
Published: (2017-02-01)

HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity
by: Tamar Tak, et al.
Published: (2021-05-01)

Exploiting embryonic niche conditions to grow Wilms tumor blastema in culture
by: Heather M. Wojcik, et al.
Published: (2023-03-01)

Stem cell therapies and glioma stem cells in glioblastoma: a systematic review of current challenges and research directions
by: Olivier Uwishema, et al.
Published: (2025-08-01)

Cancer Stem Cells – New Approach to Cancerogenensis and Treatment
by: Zuzana Mačingová, et al.
Published: (2008-01-01)

The Potential Reversible Transition between Stem Cells and Transient-Amplifying Cells: The Limbal Epithelial Stem Cell Perspective
by: Sudhir Verma, et al.
Published: (2024-04-01)

Wnt Receptor Frizzled-4 as a Marker for Isolation of Enteric Neural Progenitors in Human Children
by: Peter H. Neckel, et al.
Published: (2019-07-01)