Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site
| Published in: | ACS Omega |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2025-07-01
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| Online Access: | https://doi.org/10.1021/acsomega.5c02128 |
| _version_ | 1849535350190374912 |
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| author | Sarah E. Border Leilani M. Lotti Diaz Rasmiah Amer Abigail M. Noonchester Kayla S. Kucway Michael Fleisher Joseph P. Fernandez Alex R. Lovins Thomas S. Corrigan Ana K. Serrano Conor R. Caffrey Anthony J. O’Donoghue Don M. Benson Christopher M. Hadad Özlem Doğan Ekici |
| author_facet | Sarah E. Border Leilani M. Lotti Diaz Rasmiah Amer Abigail M. Noonchester Kayla S. Kucway Michael Fleisher Joseph P. Fernandez Alex R. Lovins Thomas S. Corrigan Ana K. Serrano Conor R. Caffrey Anthony J. O’Donoghue Don M. Benson Christopher M. Hadad Özlem Doğan Ekici |
| author_sort | Sarah E. Border |
| collection | DOAJ |
| container_title | ACS Omega |
| format | Article |
| id | doaj-art-d92d2995c2e14ea7aea1fa8aa46f2b87 |
| institution | Directory of Open Access Journals |
| issn | 2470-1343 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | American Chemical Society |
| record_format | Article |
| spelling | doaj-art-d92d2995c2e14ea7aea1fa8aa46f2b872025-08-20T02:46:08ZengAmerican Chemical SocietyACS Omega2470-13432025-07-011029315493156710.1021/acsomega.5c02128Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime SiteSarah E. Border0Leilani M. Lotti Diaz1Rasmiah Amer2Abigail M. Noonchester3Kayla S. Kucway4Michael Fleisher5Joseph P. Fernandez6Alex R. Lovins7Thomas S. Corrigan8Ana K. Serrano9Conor R. Caffrey10Anthony J. O’Donoghue11Don M. Benson12Christopher M. Hadad13Özlem Doğan Ekici14Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California, United StatesSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California, United StatesSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California, United StatesDepartment of Internal Medicine, Division of Hematology, The Ohio State University Medical Center, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United StatesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United Stateshttps://doi.org/10.1021/acsomega.5c02128 |
| spellingShingle | Sarah E. Border Leilani M. Lotti Diaz Rasmiah Amer Abigail M. Noonchester Kayla S. Kucway Michael Fleisher Joseph P. Fernandez Alex R. Lovins Thomas S. Corrigan Ana K. Serrano Conor R. Caffrey Anthony J. O’Donoghue Don M. Benson Christopher M. Hadad Özlem Doğan Ekici Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site |
| title | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site |
| title_full | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site |
| title_fullStr | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site |
| title_full_unstemmed | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site |
| title_short | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site |
| title_sort | design synthesis and evaluation of aza peptide michael acceptors as human 20s proteasome inhibitors extension to the prime site |
| url | https://doi.org/10.1021/acsomega.5c02128 |
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