Enhanced cleaning strategies for UF/DF membranes in biopharmaceutical downstream processing

Abstract Membrane fouling during ultrafiltration/diafiltration (UF/DF) remains a major challenge for extending membrane lifetime in biologics manufacturing. Developing cleaning strategies that combine high efficiency with scalability is essential for robust downstream processing. In this study, diff...

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Bibliographic Details
Published in:	Bioresources and Bioprocessing
Main Authors:	Xinye Han, Zhenhao Bian, Xuyue Han, Huaguang Wang, Han Liu, Yajuan Zhou, Yiqing Cui, Xumei Liu
Format:	Article
Language:	English
Published:	SpringerOpen 2026-04-01
Subjects:	Ultrafiltration/diafiltration (UF/DF) Membrane fouling Cleaning strategies Permeate-closed cleaning Backwashing Biologics downstream processing
Online Access:	https://doi.org/10.1186/s40643-026-01045-0

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