Implications of combined NOD2 and other gene mutations in autoinflammatory diseases

NOD-like receptors (NLRs) are intracellular sensors associated with systemic autoinflammatory diseases (SAIDs). We investigated the largest monocentric cohort of patients with adult-onset SAIDs for coinheritance of low frequency and rare mutations in NOD2 and other autoinflammatory genes. Sixty-thre...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Hafsa Nomani, Zuoming Deng, Brianne Navetta-Modrov, Jie Yang, Mark Yun, Olga Aroniadis, Peter Gorevic, Ivona Aksentijevich, Qingping Yao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	Nod2 NLRP3 NLRP12 autoinflammatory familial Mediterranean fever digenic
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265404/full