TCA cycle-derived oncometabolites in cancer and the immune microenvironment

Abstract Oncometabolites are aberrant metabolic byproducts that arise from mutations in enzymes of the tricarboxylic acid (TCA) cycle or related metabolic pathways and play central roles in tumor progression and immune evasion. Among these, 2-hydroxyglutarate (2-HG), succinate, and fumarate are the...

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Bibliographic Details
Published in:	Journal of Biomedical Science
Main Authors:	Shukla Sarkar, Chien-I Chang, Jussekia Jean, Meng-Ju Wu
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Oncometabolites 2-hydroxyglutarate Succinate Fumarate Itaconate α-ketoglutarate
Online Access:	https://doi.org/10.1186/s12929-025-01186-y

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