Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant solid tumor of digestive system, which can affect the immune system. The abnormalities of distribution, percentage, function, and activity of immune cells in both peripheral circulation and tumor microenvironment (TME) are detected in pat...
| الحاوية / القاعدة: | Waike lilun yu shijian |
|---|---|
| المؤلف الرئيسي: | |
| التنسيق: | مقال |
| اللغة: | الصينية |
| منشور في: |
Editorial Office of Journal of Surgery Concepts & Practice
2025-03-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751877237234-705100454.pdf |
| _version_ | 1849540429802897408 |
|---|---|
| author | SU Bingwei, SHEN Baiyong |
| author_facet | SU Bingwei, SHEN Baiyong |
| author_sort | SU Bingwei, SHEN Baiyong |
| collection | DOAJ |
| container_title | Waike lilun yu shijian |
| description | Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant solid tumor of digestive system, which can affect the immune system. The abnormalities of distribution, percentage, function, and activity of immune cells in both peripheral circulation and tumor microenvironment (TME) are detected in patients with PDAC. T cells are the main lymphocytes that participate in cell-mediated immunity and exert anti-tumor effects. According to the function and the cluster of differentiation, T cells can be divided into different subsets, such as CD4+, CD8+, CD4+ CD25+, etc. The abnormalities of T cell subsets in the circulating immunity and TME of patients with PDAC may play an important role in cancer progress. |
| format | Article |
| id | doaj-art-da6b2cd9121441aca0fe0fcff12ff9db |
| institution | Directory of Open Access Journals |
| issn | 1007-9610 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| spelling | doaj-art-da6b2cd9121441aca0fe0fcff12ff9db2025-08-20T02:43:47ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102025-03-0130217117510.16139/j.1007-9610.2025.02.13Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinomaSU Bingwei, SHEN Baiyong01. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China2. Department of General Surgery, Pancreatic Di-sease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine; State Key Laboratory of Oncogenes and Related Genes (Shanghai); Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200025, ChinaPancreatic ductal adenocarcinoma (PDAC) is a highly malignant solid tumor of digestive system, which can affect the immune system. The abnormalities of distribution, percentage, function, and activity of immune cells in both peripheral circulation and tumor microenvironment (TME) are detected in patients with PDAC. T cells are the main lymphocytes that participate in cell-mediated immunity and exert anti-tumor effects. According to the function and the cluster of differentiation, T cells can be divided into different subsets, such as CD4+, CD8+, CD4+ CD25+, etc. The abnormalities of T cell subsets in the circulating immunity and TME of patients with PDAC may play an important role in cancer progress.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751877237234-705100454.pdf|pancreatic ductal adenocarcinoma (pdac)|circulating immunity|tumor microenvironment (tme)|t cell subset |
| spellingShingle | SU Bingwei, SHEN Baiyong Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma |pancreatic ductal adenocarcinoma (pdac)|circulating immunity|tumor microenvironment (tme)|t cell subset |
| title | Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma |
| title_full | Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma |
| title_fullStr | Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma |
| title_full_unstemmed | Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma |
| title_short | Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma |
| title_sort | abnormalities in t cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma |
| topic | |pancreatic ductal adenocarcinoma (pdac)|circulating immunity|tumor microenvironment (tme)|t cell subset |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751877237234-705100454.pdf |
| work_keys_str_mv | AT subingweishenbaiyong abnormalitiesintcellsubsetsinthecirculatingimmunityandtumormicroenvironmentinpatientswithpancreaticductaladenocarcinoma |